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- W2286720889 endingPage "4904" @default.
- W2286720889 startingPage "4904" @default.
- W2286720889 abstract "The liver plays a key role in the metabolic conversion and elimination of endo- and xenobiotics. Hepatobiliary transport of many of these compounds is mediated by several ATP-binding cassette (ABC) transporters expressed at the canalicular membrane of the hepatocyte. Impaired function of these ABC transporters leads to impaired bile formation or cholestasis and mutations in these genes are associated with a variety of hereditary cholestatic syndromes. At the transcriptional level, these ABC transporters and the metabolizing enzymes involved in processing of their substrates are coordinately regulated by members of the nuclear receptor (NR) family of ligand-modulated transcription factors. In this review we will focus on ABC transporters involved in hepatobiliary excretion and how they are associated with hepatic physiology and disease states. We will also examine how NRs, acting as intracellular sensors for lipophilic molecules, regulate these ABC transporters and maintain metabolic homeostasis." @default.
- W2286720889 created "2016-06-24" @default.
- W2286720889 creator A5016852056 @default.
- W2286720889 creator A5046980302 @default.
- W2286720889 creator A5049828619 @default.
- W2286720889 creator A5087598197 @default.
- W2286720889 date "2009-01-01" @default.
- W2286720889 modified "2023-09-27" @default.
- W2286720889 title "Hepatobiliary ABC transporters: physiology, regulation and implications for disease" @default.
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