Matches in SemOpenAlex for { <https://semopenalex.org/work/W2286763544> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2286763544 endingPage "7" @default.
- W2286763544 startingPage "523" @default.
- W2286763544 abstract "Twenty-four nonsmoking male volunteers took 50 mg atenolol or 10 mg betaxolol orally once a day for 9 days in a two-period, four-sequence, randomized, crossover study. Plasma concentrations reached steady state after day 5. Percent fluctuation in plasma concentration defined as (Cmax-Cmin)/Cavg (% fluctuation 1) was 97% on day 9 for betaxolol and 343% for atenolol; thus atenolol fluctuation was more than threefold that of betaxolol. A 10-fold difference in plasma level fluctuation was observed when fluctuation was defined as (Cmax-Cmin)/Cmin (% fluctuation 2). The intersubject variances for % fluctuation 1 and % fluctuation 2 were 4.1 and 85.5 times greater for atenolol than for betaxolol; these differences were marginally statistically significant for % fluctuation 1 and significant for % fluctuation 2. The intrasubject variabilities for area under the curve and plasma level fluctuations were statistically greater for atenolol than for betaxolol. Atenolol intrasubject variances were 25 and 271 times greater than for betaxolol for % fluctuation 1 and % fluctuation 2, respectively. Thus, betaxolol exhibited less fluctuation in plasma levels with substantially less intersubject and intrasubject variability. These factors would be expected to provide a more consistent therapeutic response and more dependable dosage adjustment." @default.
- W2286763544 created "2016-06-24" @default.
- W2286763544 creator A5013247460 @default.
- W2286763544 creator A5019444173 @default.
- W2286763544 creator A5026488984 @default.
- W2286763544 creator A5044119653 @default.
- W2286763544 date "1989-09-01" @default.
- W2286763544 modified "2023-09-23" @default.
- W2286763544 title "Steady-state fluctuation and variability of betaxolol and atenolol plasma levels." @default.
- W2286763544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2573178" @default.
- W2286763544 hasPublicationYear "1989" @default.
- W2286763544 type Work @default.
- W2286763544 sameAs 2286763544 @default.
- W2286763544 citedByCount "2" @default.
- W2286763544 crossrefType "journal-article" @default.
- W2286763544 hasAuthorship W2286763544A5013247460 @default.
- W2286763544 hasAuthorship W2286763544A5019444173 @default.
- W2286763544 hasAuthorship W2286763544A5026488984 @default.
- W2286763544 hasAuthorship W2286763544A5044119653 @default.
- W2286763544 hasConcept C112705442 @default.
- W2286763544 hasConcept C126322002 @default.
- W2286763544 hasConcept C141071460 @default.
- W2286763544 hasConcept C142724271 @default.
- W2286763544 hasConcept C185592680 @default.
- W2286763544 hasConcept C204787440 @default.
- W2286763544 hasConcept C22979827 @default.
- W2286763544 hasConcept C27081682 @default.
- W2286763544 hasConcept C2776525901 @default.
- W2286763544 hasConcept C2778073030 @default.
- W2286763544 hasConcept C2778335254 @default.
- W2286763544 hasConcept C2779938033 @default.
- W2286763544 hasConcept C2781092963 @default.
- W2286763544 hasConcept C71924100 @default.
- W2286763544 hasConcept C84393581 @default.
- W2286763544 hasConcept C87813604 @default.
- W2286763544 hasConceptScore W2286763544C112705442 @default.
- W2286763544 hasConceptScore W2286763544C126322002 @default.
- W2286763544 hasConceptScore W2286763544C141071460 @default.
- W2286763544 hasConceptScore W2286763544C142724271 @default.
- W2286763544 hasConceptScore W2286763544C185592680 @default.
- W2286763544 hasConceptScore W2286763544C204787440 @default.
- W2286763544 hasConceptScore W2286763544C22979827 @default.
- W2286763544 hasConceptScore W2286763544C27081682 @default.
- W2286763544 hasConceptScore W2286763544C2776525901 @default.
- W2286763544 hasConceptScore W2286763544C2778073030 @default.
- W2286763544 hasConceptScore W2286763544C2778335254 @default.
- W2286763544 hasConceptScore W2286763544C2779938033 @default.
- W2286763544 hasConceptScore W2286763544C2781092963 @default.
- W2286763544 hasConceptScore W2286763544C71924100 @default.
- W2286763544 hasConceptScore W2286763544C84393581 @default.
- W2286763544 hasConceptScore W2286763544C87813604 @default.
- W2286763544 hasIssue "5" @default.
- W2286763544 hasLocation W22867635441 @default.
- W2286763544 hasOpenAccess W2286763544 @default.
- W2286763544 hasPrimaryLocation W22867635441 @default.
- W2286763544 hasRelatedWork W1498281456 @default.
- W2286763544 hasRelatedWork W1834450669 @default.
- W2286763544 hasRelatedWork W1987839943 @default.
- W2286763544 hasRelatedWork W2068670139 @default.
- W2286763544 hasRelatedWork W2071803893 @default.
- W2286763544 hasRelatedWork W2088451344 @default.
- W2286763544 hasRelatedWork W2090795943 @default.
- W2286763544 hasRelatedWork W2286763544 @default.
- W2286763544 hasRelatedWork W2403522199 @default.
- W2286763544 hasRelatedWork W2505509231 @default.
- W2286763544 hasVolume "11" @default.
- W2286763544 isParatext "false" @default.
- W2286763544 isRetracted "false" @default.
- W2286763544 magId "2286763544" @default.
- W2286763544 workType "article" @default.