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- W2286784181 abstract "It has been reported that the caudal ventrolateral medulla (VLM) is important in central chemoreception and the control of breathing. The objective of this study was to determine in adult goats the effects on breathing of neuronal dysfunction of this caudal VLM region (area L; caudal to rostral hypoglossal nerve rootlet). Thermodes were chronically implanted on the VLM to cool neurons and thereby cause neuronal dysfunction. During awake and (halothane) anesthetized states, cooling the caudal VLM for 20 s to 20 degrees C did not alter breathing (P > 0.10). However, between 20 and 30 s of cooling and during recovery from cooling 0-4 mm caudal to the rostral hypoglossal rootlet, there was a 12 (awake) to 25% (anesthetized) increase (P < 0.05) in breathing. This tachypneic hyperpnea was uniform over conditions of eucapnia, hypercapnia, and hypoxia and resulted from reduced inspiratory time that increased frequency. We conclude that in goats inhibitory neurons are located in area L and the lateral caudal ventral medulla." @default.
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- W2286784181 date "1995-11-01" @default.
- W2286784181 modified "2023-10-12" @default.
- W2286784181 title "Effect on breathing of neuronal dysfunction in the caudal ventral medulla of goats" @default.
- W2286784181 doi "https://doi.org/10.1152/jappl.1995.79.5.1586" @default.
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