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• W2286797029 endingPage "1293" @default.
• W2286797029 startingPage "1282" @default.
• W2286797029 abstract "Nonalcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome. Overconsumption of high-fat diet (HFD) and increased intake of sugar-sweetened beverages are major risk factors for development of NAFLD. Today the most commonly consumed sugar is high fructose corn syrup. Hepatic lipids may be derived from dietary intake, esterification of plasma free fatty acids (FFA) or hepatic de novo lipogenesis (DNL). A central abnormality in NAFLD is enhanced DNL. Hepatic DNL is increased in individuals with NAFLD, while the contribution of dietary fat and plasma FFA to hepatic lipids is not significantly altered. The importance of DNL in NAFLD is further established in mouse studies with knockout of genes involved in this process. Dietary fructose increases levels of enzymes involved in DNL even more strongly than HFD. Several properties of fructose metabolism make it particularly lipogenic. Fructose is absorbed via portal vein and delivered to the liver in much higher concentrations as compared to other tissues. Fructose increases protein levels of all DNL enzymes during its conversion into triglycerides. Additionally, fructose supports lipogenesis in the setting of insulin resistance as fructose does not require insulin for its metabolism, and it directly stimulates SREBP1c, a major transcriptional regulator of DNL. Fructose also leads to ATP depletion and suppression of mitochondrial fatty acid oxidation, resulting in increased production of reactive oxygen species. Furthermore, fructose promotes ER stress and uric acid formation, additional insulin independent pathways leading to DNL. In summary, fructose metabolism supports DNL more strongly than HFD and hepatic DNL is a central abnormality in NAFLD. Disrupting fructose metabolism in the liver may provide a new therapeutic option for the treatment of NAFLD." @default.
• W2286797029 created "2016-06-24" @default.
• W2286797029 creator A5004209066 @default.
• W2286797029 creator A5037042684 @default.
• W2286797029 creator A5060130735 @default.
• W2286797029 date "2016-02-08" @default.
• W2286797029 modified "2023-10-15" @default.
• W2286797029 title "Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease" @default.
• W2286797029 cites W111603817 @default.
• W2286797029 cites W1608611896 @default.
• W2286797029 cites W1769215855 @default.
• W2286797029 cites W1886727246 @default.
• W2286797029 cites W1934420673 @default.
• W2286797029 cites W1964240866 @default.
• W2286797029 cites W1969405537 @default.
• W2286797029 cites W1969734540 @default.
• W2286797029 cites W1972744939 @default.
• W2286797029 cites W1973054593 @default.
• W2286797029 cites W1974548821 @default.
• W2286797029 cites W1975545121 @default.
• W2286797029 cites W1976094170 @default.
• W2286797029 cites W1980954879 @default.
• W2286797029 cites W1980992924 @default.
• W2286797029 cites W1984202231 @default.
• W2286797029 cites W1985592156 @default.
• W2286797029 cites W1987934823 @default.
• W2286797029 cites W1988364643 @default.
• W2286797029 cites W1989912256 @default.
• W2286797029 cites W1994261934 @default.
• W2286797029 cites W1998493448 @default.
• W2286797029 cites W1998984659 @default.
• W2286797029 cites W1999950621 @default.
• W2286797029 cites W2000511685 @default.
• W2286797029 cites W2002226939 @default.
• W2286797029 cites W2002349285 @default.
• W2286797029 cites W2007486805 @default.
• W2286797029 cites W2012652496 @default.
• W2286797029 cites W2017948134 @default.
• W2286797029 cites W2019973807 @default.
• W2286797029 cites W2020279945 @default.
• W2286797029 cites W2023668384 @default.
• W2286797029 cites W2026241394 @default.
• W2286797029 cites W2027519382 @default.
• W2286797029 cites W2028874440 @default.
• W2286797029 cites W2030610610 @default.
• W2286797029 cites W2030901818 @default.
• W2286797029 cites W2034046497 @default.
• W2286797029 cites W2034073943 @default.
• W2286797029 cites W2034084750 @default.
• W2286797029 cites W2034700421 @default.
• W2286797029 cites W2037918682 @default.
• W2286797029 cites W2039890062 @default.
• W2286797029 cites W2041572943 @default.
• W2286797029 cites W2044100362 @default.
• W2286797029 cites W2046113619 @default.
• W2286797029 cites W2047470062 @default.
• W2286797029 cites W2048375374 @default.
• W2286797029 cites W2053500970 @default.
• W2286797029 cites W2055382292 @default.
• W2286797029 cites W2057410422 @default.
• W2286797029 cites W2058749852 @default.
• W2286797029 cites W2060968396 @default.
• W2286797029 cites W2063007022 @default.
• W2286797029 cites W2063086702 @default.
• W2286797029 cites W2067740038 @default.
• W2286797029 cites W2068423669 @default.
• W2286797029 cites W2068565795 @default.
• W2286797029 cites W2073387842 @default.
• W2286797029 cites W2074076323 @default.
• W2286797029 cites W2078827546 @default.
• W2286797029 cites W2079505895 @default.
• W2286797029 cites W2081112865 @default.
• W2286797029 cites W2083511523 @default.
• W2286797029 cites W2085097924 @default.
• W2286797029 cites W2085336832 @default.
• W2286797029 cites W2085485546 @default.
• W2286797029 cites W2086717868 @default.
• W2286797029 cites W2087410169 @default.
• W2286797029 cites W2089046390 @default.
• W2286797029 cites W2089369126 @default.
• W2286797029 cites W2090063543 @default.
• W2286797029 cites W2090415246 @default.
• W2286797029 cites W2091770605 @default.
• W2286797029 cites W2091994022 @default.
• W2286797029 cites W2092537435 @default.
• W2286797029 cites W2093824918 @default.
• W2286797029 cites W2097270759 @default.
• W2286797029 cites W2097672374 @default.
• W2286797029 cites W2098012175 @default.
• W2286797029 cites W2098260346 @default.
• W2286797029 cites W2098394215 @default.
• W2286797029 cites W2101530263 @default.
• W2286797029 cites W2102105249 @default.
• W2286797029 cites W2102767551 @default.
• W2286797029 cites W2103991787 @default.
• W2286797029 cites W2106061083 @default.
• W2286797029 cites W2107541102 @default.
• W2286797029 cites W2109069233 @default.

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