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- W2286804562 abstract "The miR-294/miR-302 microRNAs promote the abbreviated G1 phase of the embryonic stem cell(ESC) cell cycle and suppress differentiation induced by let-7. Here we evaluated the role of theRetinoblastoma (Rb) family proteins in these settings. Under normal growth conditions miR-294promoted the rapid G1-S transition independent of the Rb family. In contrast, miR-294 suppressedthe further accumulation of cells in G1 in response to nutrient deprivation and cell-cell contact inan Rb dependent fashion. We uncovered five additional miRNAs (miRs-26a, -99b, -193, -199a-5p,and 218) that silenced ESC self-renewal in the absence of other miRNAs, all of which wereantagonized by miR-294/302. Four of the six differentiation-inducing miRNAs induced an RbdependentG1 accumulation. However, all six still silenced self-renewal in the absence of the Rbproteins. These results show that the miR-294/miR-302 family acts through Rb dependent andindependent pathways to regulate the G1 restriction point and the silencing of self-renewalrespectively." @default.
- W2286804562 created "2016-06-24" @default.
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- W2286804562 date "2013-07-01" @default.
- W2286804562 modified "2023-09-26" @default.
- W2286804562 title "MiR-294/-302 promotes proliferation, suppresses G1-Srestriction point, and inhibits embryonic stem cell differentiationthrough separable mechanisms" @default.
- W2286804562 hasPublicationYear "2013" @default.
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