Matches in SemOpenAlex for { <https://semopenalex.org/work/W2287081661> ?p ?o ?g. }
- W2287081661 endingPage "86" @default.
- W2287081661 startingPage "72" @default.
- W2287081661 abstract "Antiepileptic drugs (AEDs) are frequently co-prescribed with new antidepressants (ADs) or new antipsychotics (APs). A PubMed search with no time limit was used to update the review of the clinically significant pharmacokinetic (PK) drug interactions DIs (DIs) between AEDs with new ADs and APs. Our best interpretation of what to expect regarding dosing changes in the average patient after combining AEDs with new ADs or new APs is summarized on updated tables that integrate the information on in vitro metabolism studies, therapeutic drug monitoring (TDM) studies, case report/series and prospective studies. There will be a need to periodically update these dose correction factors as new knowledge becomes available. These tables will provide some orientation to clinicians with no TDM access and may also encourage clinicians to further study TDM. The clinical relevance of the inductive properties of carbamazepine, phenytoin, phenobarbital and primidone on new ADs and new APs and the inhibitory properties of valproic acid and some new ADs, are relatively well understood. On the other hand, PK DI studies combining new AEDs with weak inductive properties (particularly oxcarbazepine doses ≥ 1200 mg/day), topiramate doses ≥ 400 mg/day, clobazam, eslicarbazepine, and rufinamide), with new ADs and new APs are needed. Valproic acid may be 1) an inhibitor and/or inducer of clozapine and olanzapine with potential for clinically relevant DIs, 2) an inhibitor of paliperidone, and 3) a weak inducer of aripiprazole. Fluoxetine and fluvoxamine are relevant inhibitors of phenytoin and valproic acid and possibly of clobazam, lacosamide, phenobarbital, or primidone." @default.
- W2287081661 created "2016-06-24" @default.
- W2287081661 creator A5056735832 @default.
- W2287081661 creator A5071289483 @default.
- W2287081661 creator A5082054712 @default.
- W2287081661 date "2016-04-01" @default.
- W2287081661 modified "2023-10-16" @default.
- W2287081661 title "Clinically significant pharmacokinetic drug interactions of antiepileptic drugs with new antidepressants and new antipsychotics" @default.
- W2287081661 cites W119436965 @default.
- W2287081661 cites W1501777540 @default.
- W2287081661 cites W1569270003 @default.
- W2287081661 cites W1581302994 @default.
- W2287081661 cites W1607338306 @default.
- W2287081661 cites W1852599253 @default.
- W2287081661 cites W1931239046 @default.
- W2287081661 cites W1960629422 @default.
- W2287081661 cites W1964525922 @default.
- W2287081661 cites W1966053655 @default.
- W2287081661 cites W1968067130 @default.
- W2287081661 cites W1969114959 @default.
- W2287081661 cites W1969704975 @default.
- W2287081661 cites W1969841440 @default.
- W2287081661 cites W1970309276 @default.
- W2287081661 cites W1970773512 @default.
- W2287081661 cites W1970908493 @default.
- W2287081661 cites W1970985273 @default.
- W2287081661 cites W1971335539 @default.
- W2287081661 cites W1971546329 @default.
- W2287081661 cites W1972041009 @default.
- W2287081661 cites W1973870546 @default.
- W2287081661 cites W1975490782 @default.
- W2287081661 cites W1976411805 @default.
- W2287081661 cites W1978551870 @default.
- W2287081661 cites W1979980024 @default.
- W2287081661 cites W1981455112 @default.
- W2287081661 cites W1982141750 @default.
- W2287081661 cites W1983075476 @default.
- W2287081661 cites W1983595576 @default.
- W2287081661 cites W1984744953 @default.
- W2287081661 cites W1985155015 @default.
- W2287081661 cites W1987886416 @default.
- W2287081661 cites W1989762378 @default.
- W2287081661 cites W1991796054 @default.
- W2287081661 cites W1993007848 @default.
- W2287081661 cites W1993859290 @default.
- W2287081661 cites W1994733841 @default.
- W2287081661 cites W1996261168 @default.
- W2287081661 cites W1996854327 @default.
- W2287081661 cites W2010243793 @default.
- W2287081661 cites W2010680811 @default.
- W2287081661 cites W2013430629 @default.
- W2287081661 cites W2016421017 @default.
- W2287081661 cites W2017376714 @default.
- W2287081661 cites W2017986127 @default.
- W2287081661 cites W2019559657 @default.
- W2287081661 cites W2019997974 @default.
- W2287081661 cites W2023515449 @default.
- W2287081661 cites W2023938946 @default.
- W2287081661 cites W2025721032 @default.
- W2287081661 cites W2032865655 @default.
- W2287081661 cites W2033342358 @default.
- W2287081661 cites W2033614870 @default.
- W2287081661 cites W2037292769 @default.
- W2287081661 cites W2037608619 @default.
- W2287081661 cites W2039171352 @default.
- W2287081661 cites W2044976930 @default.
- W2287081661 cites W2045415800 @default.
- W2287081661 cites W2047046946 @default.
- W2287081661 cites W2047075668 @default.
- W2287081661 cites W2048406730 @default.
- W2287081661 cites W2049153554 @default.
- W2287081661 cites W2053109751 @default.
- W2287081661 cites W2053399522 @default.
- W2287081661 cites W2055369912 @default.
- W2287081661 cites W2059743980 @default.
- W2287081661 cites W206039361 @default.
- W2287081661 cites W2066219109 @default.
- W2287081661 cites W2069799317 @default.
- W2287081661 cites W2069987842 @default.
- W2287081661 cites W2071517082 @default.
- W2287081661 cites W2073280978 @default.
- W2287081661 cites W2073310864 @default.
- W2287081661 cites W2073975093 @default.
- W2287081661 cites W2074165712 @default.
- W2287081661 cites W2075094571 @default.
- W2287081661 cites W2076385317 @default.
- W2287081661 cites W2077900895 @default.
- W2287081661 cites W2079547615 @default.
- W2287081661 cites W2080724513 @default.
- W2287081661 cites W2081376585 @default.
- W2287081661 cites W2085696296 @default.
- W2287081661 cites W2086036313 @default.
- W2287081661 cites W2091300673 @default.
- W2287081661 cites W2092084608 @default.
- W2287081661 cites W2096059646 @default.
- W2287081661 cites W2096739998 @default.
- W2287081661 cites W2105015425 @default.
- W2287081661 cites W2110694855 @default.