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- W2287187892 abstract "Immunoassay performance is a function of the affinity and selectivity of the antibody. The immunizing hapten should represent a near perfect mimic of the target molecule in structure, electronic and hydrophobic properties. These haptens are tethered with an antigenically inert handle distal to the determinant group(s) and do not mask or alter any functional group. Optimal hapten design criteria are based on extending an existing carbon chain, or replacing a C-H moiety of the target molecule with a CH2 chain terminated by a functional group for conjugation to proteins. Careful selection of immunizing hapten can lead to the production of compound or class selective antibodies. A multiple hapten approach, based on handle location, length, and composition, results in assays with sub-ppb levels of detection and improved selectivity. Examination of cross-reactivity data of the haptens led to the identification of the best coating/enzyme-labeled haptens for improved heterologous assays. Examples from research with triazine, arylurea,and chloracetanilide pesticides illustrate these principles." @default.
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- W2287187892 date "1995-03-23" @default.
- W2287187892 modified "2023-10-10" @default.
- W2287187892 title "Strategies for Immunoassay Hapten Design" @default.
- W2287187892 doi "https://doi.org/10.1021/bk-1995-0586.ch009" @default.
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