FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2287225180> ?p ?o ?g. }

• W2287225180 startingPage "4" @default.
• W2287225180 abstract "Depression treatment seems to be in a funk these days. Armchair critics, some of whom have never treated a depressed patient, are flooding the media and Internet with allegations that antidepressants--which have helped patients for decades--are no better than placebo. Several major pharmaceutical companies have pared down or shut down their CNS discovery, research, and development operations. There is a lack of new antidepressants with novel mechanisms of action, and the proportion of refractory or treatment-resistant depression (TRD) seems to be growing. In short, the status of clinical depression seems rather depressing. [ILLUSTRATION OMITTED] Yet nothing can be further from the truth! A vibrant set of innovative, even radical, solutions for TRD are on the horizon. Here are some of the paradigm shifts in the neurobiology and therapeutics of major depression that gradually are toppling decades-old tenets and creeds related to this serious psychiatric disorder: From genes vs environment to gene x environment interaction. For decades, it was assumed that some people have endogenous depression due to genetic determinants, while others are afflicted with exogenous depression caused by stressful life events. The new model shows that the environment interacts with genes to produce depression, and that having only risk genes or only environmental stress does not necessarily lead to depression. (1) From 'chemical imbalance' to 'inflammatory process: Evidence is accumulating that inflammation may be underpinning depression, (2) and studies show levels of inflammatory cytokines and interleukins rise during a depressive episode and decline when the depression remits. From 'neurotransmitters' to 'neuroplasticity and neurotropic factors: Current treatments were developed to increase neurotransmitter activity in the brain, but new research reveals that depression is associated with a significant drop in neurotropic factors such as brain derived neurotropic factor (BDNF) or fibroblast growth factor with a concomitant decline in hippocampal neurogenesis. (3) From serotonin, norepinephrine, and dopamine to glutamate. Over the past few years, glutamate pathways and the glutamate N-methyl-D-aspartate (NMDA) receptor have emerged as possibly of central importance to the neurobiology of depression. (4) The link between the strong therapeutic effects of antagonizing the NMDA receptor in depression and the increase in BDNF and neuroplasticity has emerged as a fresh model of depression. From pills to intravenous infusions. Studies have shown that a single infusion of the NMDA receptor antagonist ketamine produces a very robust response, including full remission, in treatment resistant unipolar or bipolar depression within 1 to 2 hours! (5) The mechanism of action has been attributed to a surge of BDNF and immediate neuroplastic changes (4) following NMDA receptor blockade. This abrupt reversal of severe depression, like turning on a switch, is a total and pleasant surprise. From monotherapy to augmentation strategies. The rather imprudent notion that a single medication can be effective in a heterogeneous spectrum of disorders such as depression gradually is yielding to intelligent polypharmacy, using evidence-based augmentation strategies that might include lithium, thyroid hormone, another antidepressant (particularly mirtazapine), atypical antipsychotics, anti-inflammatory agents (including omega-3 fatty acids), antioxidants (especially N-acetylcysteine), L-methylfolate, and exercise. …" @default.
• W2287225180 created "2016-06-24" @default.
• W2287225180 creator A5084051141 @default.
• W2287225180 date "2012-06-01" @default.
• W2287225180 modified "2023-09-27" @default.
• W2287225180 title "Innovative Approaches to Treatment-Resistant Depression" @default.
• W2287225180 cites W2077672919 @default.
• W2287225180 cites W2089198034 @default.
• W2287225180 cites W2089351762 @default.
• W2287225180 cites W2102561947 @default.
• W2287225180 cites W2109334244 @default.
• W2287225180 cites W2132098276 @default.
• W2287225180 cites W2162196924 @default.
• W2287225180 cites W2777987555 @default.
• W2287225180 hasPublicationYear "2012" @default.
• W2287225180 type Work @default.
• W2287225180 sameAs 2287225180 @default.
• W2287225180 citedByCount "1" @default.
• W2287225180 countsByYear W22872251802013 @default.
• W2287225180 crossrefType "journal-article" @default.
• W2287225180 hasAuthorship W2287225180A5084051141 @default.
• W2287225180 hasConcept C118552586 @default.
• W2287225180 hasConcept C139719470 @default.
• W2287225180 hasConcept C15744967 @default.
• W2287225180 hasConcept C162324750 @default.
• W2287225180 hasConcept C2776867660 @default.
• W2287225180 hasConcept C2780051608 @default.
• W2287225180 hasConcept C2780733359 @default.
• W2287225180 hasConcept C71924100 @default.
• W2287225180 hasConceptScore W2287225180C118552586 @default.
• W2287225180 hasConceptScore W2287225180C139719470 @default.
• W2287225180 hasConceptScore W2287225180C15744967 @default.
• W2287225180 hasConceptScore W2287225180C162324750 @default.
• W2287225180 hasConceptScore W2287225180C2776867660 @default.
• W2287225180 hasConceptScore W2287225180C2780051608 @default.
• W2287225180 hasConceptScore W2287225180C2780733359 @default.
• W2287225180 hasConceptScore W2287225180C71924100 @default.
• W2287225180 hasIssue "6" @default.
• W2287225180 hasLocation W22872251801 @default.
• W2287225180 hasOpenAccess W2287225180 @default.
• W2287225180 hasPrimaryLocation W22872251801 @default.
• W2287225180 hasRelatedWork W2018650846 @default.
• W2287225180 hasRelatedWork W2040624569 @default.
• W2287225180 hasRelatedWork W2158477548 @default.
• W2287225180 hasRelatedWork W2164672521 @default.
• W2287225180 hasRelatedWork W2212718623 @default.
• W2287225180 hasRelatedWork W2318551008 @default.
• W2287225180 hasRelatedWork W2321604720 @default.
• W2287225180 hasRelatedWork W2409732157 @default.
• W2287225180 hasRelatedWork W2431378091 @default.
• W2287225180 hasRelatedWork W2469221759 @default.
• W2287225180 hasRelatedWork W2620630426 @default.
• W2287225180 hasRelatedWork W2785838524 @default.
• W2287225180 hasRelatedWork W2793018290 @default.
• W2287225180 hasRelatedWork W3020972479 @default.
• W2287225180 hasRelatedWork W3128019732 @default.
• W2287225180 hasRelatedWork W3187753905 @default.
• W2287225180 hasRelatedWork W50994410 @default.
• W2287225180 hasRelatedWork W72199885 @default.
• W2287225180 hasRelatedWork W2005176180 @default.
• W2287225180 hasRelatedWork W2188359060 @default.
• W2287225180 hasVolume "11" @default.
• W2287225180 isParatext "false" @default.
• W2287225180 isRetracted "false" @default.
• W2287225180 magId "2287225180" @default.
• W2287225180 workType "article" @default.