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- W2287272046 abstract "G A A b st ra ct s concentration of EtOH (100 mM) for 24h reduced the expression of AQPs (20-30 and 3040% vs. the controls, respectively). Notably, there was a substantial recovery of the expression of AQPs at 48h in the GCDC or EtOH treated cells but not in the CDC-treated cells. 24h treatment with 20 ng/ml TNF-α downregulated the expression of AQP1, -5 and -6 (2040% vs. the controls). Immunocytochemical analyses showed that the protein expression levels of both AQP3 and -5 dose-dependently decreased in response to the above mentioned toxic agents. Conclusion. AQP1, -3, -5, -6 and -11 are highly expressed in CAPAN-1 cells. Pancreatitis-inducing agents strongly downregulate the expression of AQPs both at mRNA and protein levels; therefore, may play a crucial role in the diminished fluid secretion during acute pancreatitis. The authors have no disclosures to declare. This work was supported by the Hungarian Scientific Research Fund (OTKA), the Hungarian Academy of Sciences (MTA) and the National Development Agency (TAMOP)." @default.
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- W2287272046 date "2012-05-01" @default.
- W2287272046 modified "2023-09-25" @default.
- W2287272046 title "Sa1485 Inhibitory Activity of Pancreatic Apelin on Neutrophil Infiltration and Systemic Cytokine Levels During Acute Pancreatitis" @default.
- W2287272046 doi "https://doi.org/10.1016/s0016-5085(12)61192-5" @default.
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