Matches in SemOpenAlex for { <https://semopenalex.org/work/W2287284178> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2287284178 endingPage "11" @default.
- W2287284178 startingPage "908" @default.
- W2287284178 abstract "To investigate the genotypes and clinical features of children with HbH disease in Guangxi Zhuang Autonomous Region, China.A total of 595 children from Guangxi were recruited. Single-tube multiplex polymerase chain reaction combined with agarose gel electrophoresis, as well as reverse dot blotting, were performed to detect the three α-globin gene deletion mutations (--(SEA), -α(3.7), and -α(4.2)) and three non-deletion mutations (Hb Westmead, Hb Constant Spring, and Hb Quong Sze) which are common in the Chinese population.Among the 595 cases, five common genotypes were identified, which were --(SEA)/-α(3.7) (232 cases), --(SEA)/α(CS)α (174 cases), --(SEA)/-α(4.2) (122 cases), --(SEA)/α(WS)α (35 cases), and --(SEA)/α(QS)α (24 cases). The genotype of THAI deletion associated with α-thalassemia-2 was detected in eight cases. Six β-mutations including CD41-42, CD17-28, CD26, IVS-II-654, IVS-I-1, and CD27-28 were identified in 23 cases. All children with HbH disease had microcytic hypochromic anemia; children with HbH-CS disease had the most severe anemia, and those with HbH-WS disease had the mildest anemia.Deletional HbH disease is the main type in children with HbH disease in Guangxi, and some patients also have mild beta-thalassemia. Non-deletional HbH disease shows more severe phenotype than deletional HbH disease." @default.
- W2287284178 created "2016-06-24" @default.
- W2287284178 creator A5003376539 @default.
- W2287284178 creator A5030433895 @default.
- W2287284178 creator A5032087843 @default.
- W2287284178 creator A5036011994 @default.
- W2287284178 creator A5039759980 @default.
- W2287284178 creator A5039837606 @default.
- W2287284178 creator A5050922378 @default.
- W2287284178 creator A5070306053 @default.
- W2287284178 date "2015-09-01" @default.
- W2287284178 modified "2023-10-02" @default.
- W2287284178 title "[Genotypes and clinical features of 595 children with HbH disease in Guangxi, China]." @default.
- W2287284178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26412168" @default.
- W2287284178 hasPublicationYear "2015" @default.
- W2287284178 type Work @default.
- W2287284178 sameAs 2287284178 @default.
- W2287284178 citedByCount "0" @default.
- W2287284178 crossrefType "journal-article" @default.
- W2287284178 hasAuthorship W2287284178A5003376539 @default.
- W2287284178 hasAuthorship W2287284178A5030433895 @default.
- W2287284178 hasAuthorship W2287284178A5032087843 @default.
- W2287284178 hasAuthorship W2287284178A5036011994 @default.
- W2287284178 hasAuthorship W2287284178A5039759980 @default.
- W2287284178 hasAuthorship W2287284178A5039837606 @default.
- W2287284178 hasAuthorship W2287284178A5050922378 @default.
- W2287284178 hasAuthorship W2287284178A5070306053 @default.
- W2287284178 hasConcept C104317684 @default.
- W2287284178 hasConcept C126322002 @default.
- W2287284178 hasConcept C135763542 @default.
- W2287284178 hasConcept C2778248108 @default.
- W2287284178 hasConcept C2781376033 @default.
- W2287284178 hasConcept C49105822 @default.
- W2287284178 hasConcept C54355233 @default.
- W2287284178 hasConcept C71924100 @default.
- W2287284178 hasConcept C86803240 @default.
- W2287284178 hasConceptScore W2287284178C104317684 @default.
- W2287284178 hasConceptScore W2287284178C126322002 @default.
- W2287284178 hasConceptScore W2287284178C135763542 @default.
- W2287284178 hasConceptScore W2287284178C2778248108 @default.
- W2287284178 hasConceptScore W2287284178C2781376033 @default.
- W2287284178 hasConceptScore W2287284178C49105822 @default.
- W2287284178 hasConceptScore W2287284178C54355233 @default.
- W2287284178 hasConceptScore W2287284178C71924100 @default.
- W2287284178 hasConceptScore W2287284178C86803240 @default.
- W2287284178 hasIssue "9" @default.
- W2287284178 hasLocation W22872841781 @default.
- W2287284178 hasOpenAccess W2287284178 @default.
- W2287284178 hasPrimaryLocation W22872841781 @default.
- W2287284178 hasRelatedWork W10000712 @default.
- W2287284178 hasRelatedWork W1999633340 @default.
- W2287284178 hasRelatedWork W2008212914 @default.
- W2287284178 hasRelatedWork W2011532883 @default.
- W2287284178 hasRelatedWork W2124345793 @default.
- W2287284178 hasRelatedWork W2285734893 @default.
- W2287284178 hasRelatedWork W2761367472 @default.
- W2287284178 hasRelatedWork W3013453526 @default.
- W2287284178 hasRelatedWork W3089758010 @default.
- W2287284178 hasRelatedWork W4242671891 @default.
- W2287284178 hasVolume "17" @default.
- W2287284178 isParatext "false" @default.
- W2287284178 isRetracted "false" @default.
- W2287284178 magId "2287284178" @default.
- W2287284178 workType "article" @default.