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• W2287285498 abstract "Objective Sleep maintenance challenges in patients with DS are commonly associated with sleep disordered breathing (SDB). WED/RLS, which is a frequent cause of insomnia, has never been investigated as a possible cause. We investigated WED/RLS in patients with DS. Methods Patients were assessed with qualitative methodology, using narrative schema, therapeutic emplotment and behavioural observations. Familial WED was diagnosed clinically with familial sleep/wake-behaviour history, and the suggested clinical immobilization test (SCIT). Clinical presentations and symptoms were captured in reports, distributed to parents/caregivers and therapists for quality control, and recorded retrospectively in a clinical phenotyping database. Results We describe a cohort of 16 patients with DS (mean 8y; median 6y; min 2y/max 26y): all patients exhibited histories and behaviours, including positive informal SCIT, suggestive of WED (75% familial; 25% non-familial); 56% had suspected or confirmed periodic limb movements. 75% experienced insomnia (75% sleep maintenance; 50% difficulties falling asleep) and 19% experienced secondary behavioural insomnia. 94% presented with SDB: 75% mouth breathing, 63% snoring, 44% witnessed apnea/hypopnea (either currently or historically), and 31% had an atypical head position/reclined head during sleep despite surgical interventions in 31% of patients. 4 patients had an ASD diagnosis and 1 had an FASD diagnosis. Conclusion Along with SDB, (familial) WED might play a significant role in children with DS, which has been missed until now. The typical symptom of difficulties falling asleep may not be apparent as patients with DS experience significant daytime sleepiness due to their chronic sleep deprivation and non-restorative sleep. Acknowledgement: TIDE-BC (Treatable Intellectual Disability Endeavour – British Columbia) & Children's Sleep Network, both Vancouver, Canada; Down Syndrome Research Foundation (DSRF), Burnaby, Canada. Sleep maintenance challenges in patients with DS are commonly associated with sleep disordered breathing (SDB). WED/RLS, which is a frequent cause of insomnia, has never been investigated as a possible cause. We investigated WED/RLS in patients with DS. Patients were assessed with qualitative methodology, using narrative schema, therapeutic emplotment and behavioural observations. Familial WED was diagnosed clinically with familial sleep/wake-behaviour history, and the suggested clinical immobilization test (SCIT). Clinical presentations and symptoms were captured in reports, distributed to parents/caregivers and therapists for quality control, and recorded retrospectively in a clinical phenotyping database. We describe a cohort of 16 patients with DS (mean 8y; median 6y; min 2y/max 26y): all patients exhibited histories and behaviours, including positive informal SCIT, suggestive of WED (75% familial; 25% non-familial); 56% had suspected or confirmed periodic limb movements. 75% experienced insomnia (75% sleep maintenance; 50% difficulties falling asleep) and 19% experienced secondary behavioural insomnia. 94% presented with SDB: 75% mouth breathing, 63% snoring, 44% witnessed apnea/hypopnea (either currently or historically), and 31% had an atypical head position/reclined head during sleep despite surgical interventions in 31% of patients. 4 patients had an ASD diagnosis and 1 had an FASD diagnosis. Along with SDB, (familial) WED might play a significant role in children with DS, which has been missed until now. The typical symptom of difficulties falling asleep may not be apparent as patients with DS experience significant daytime sleepiness due to their chronic sleep deprivation and non-restorative sleep. Acknowledgement: TIDE-BC (Treatable Intellectual Disability Endeavour – British Columbia) & Children's Sleep Network, both Vancouver, Canada; Down Syndrome Research Foundation (DSRF), Burnaby, Canada." @default.
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• W2287285498 date "2015-05-01" @default.
• W2287285498 modified "2023-09-26" @default.
• W2287285498 title "P152 – 2914: Falling asleep and sleep maintenance challenges due to Willis-Ekbom disease/restless legs syndrome (WED/RLS) in children with Down syndrome (DS)" @default.
• W2287285498 doi "https://doi.org/10.1016/s1090-3798(15)30465-7" @default.
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