FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2287302588> ?p ?o ?g. }

• W2287302588 endingPage "323" @default.
• W2287302588 startingPage "313" @default.
• W2287302588 abstract "There is considerable variability in the extent and nature of the glial response to injury and neurodegeneration. Transplantation of fetal cortical tissue onto the brain of neonatal host rats or mice results in region-specific changes dependent on where the fetal tissue is placed. These changes include chronic astrocytic and microglial gliosis, oxidative stress, and altered metabolism of a number of proteins associated with the pathogenesis of Alzheimer's disease. Such changes are only observed in heterotopic (cortex-to-midbrain) grafts and are not observed in homotopic cortex-to-cortex grafts. We investigated two possible triggers for the region-specific gliosis observed in our transplant model hypothesizing that either i) poor vascularization and lack of blood brain barrier integrity or ii) an inflammatory response initiated by the transplantation process, contributed to establishing chronic pathological changes.We analyzed the time course of neovascularization, blood brain barrier permeability and inflammation using a combination of immunohistochemistry, enzyme-linked immunosorbant assay and Evan's blue dye extravasation techniques.Blood brain barrier permeability and altered neovascularization occurred prior to the onset of gliosis in heterotopic grafts.These data suggest that ischemic conditions and blood brain barrier damage can be a primary mechanism that initiates chronic gliosis and associated inflammatory changes in central nervous system tissue." @default.
• W2287302588 created "2016-06-24" @default.
• W2287302588 creator A5016525500 @default.
• W2287302588 creator A5063931891 @default.
• W2287302588 creator A5070387545 @default.
• W2287302588 creator A5072544096 @default.
• W2287302588 date "2016-03-21" @default.
• W2287302588 modified "2023-09-27" @default.
• W2287302588 title "Vascular insufficiency, not inflammation, contributes to chronic gliosis in a rat CNS transplantation model" @default.
• W2287302588 cites W1045311631 @default.
• W2287302588 cites W1533942347 @default.
• W2287302588 cites W1964369365 @default.
• W2287302588 cites W1969619562 @default.
• W2287302588 cites W1974294728 @default.
• W2287302588 cites W1975483277 @default.
• W2287302588 cites W1977838764 @default.
• W2287302588 cites W1979228875 @default.
• W2287302588 cites W1980147688 @default.
• W2287302588 cites W1980201406 @default.
• W2287302588 cites W1980286690 @default.
• W2287302588 cites W1983712592 @default.
• W2287302588 cites W1989706524 @default.
• W2287302588 cites W1992159395 @default.
• W2287302588 cites W1996243257 @default.
• W2287302588 cites W1999495459 @default.
• W2287302588 cites W2012586359 @default.
• W2287302588 cites W2015551349 @default.
• W2287302588 cites W2016866257 @default.
• W2287302588 cites W2023273195 @default.
• W2287302588 cites W2024353040 @default.
• W2287302588 cites W2033215199 @default.
• W2287302588 cites W2034606159 @default.
• W2287302588 cites W2038815058 @default.
• W2287302588 cites W2043375698 @default.
• W2287302588 cites W2043622310 @default.
• W2287302588 cites W2045232834 @default.
• W2287302588 cites W2047585900 @default.
• W2287302588 cites W2050996473 @default.
• W2287302588 cites W2051536500 @default.
• W2287302588 cites W2052334681 @default.
• W2287302588 cites W2058147593 @default.
• W2287302588 cites W2059172386 @default.
• W2287302588 cites W2059368005 @default.
• W2287302588 cites W2060506116 @default.
• W2287302588 cites W2060818048 @default.
• W2287302588 cites W2063693202 @default.
• W2287302588 cites W2068083739 @default.
• W2287302588 cites W2079905804 @default.
• W2287302588 cites W2084566588 @default.
• W2287302588 cites W2085424855 @default.
• W2287302588 cites W2086436146 @default.
• W2287302588 cites W2089573535 @default.
• W2287302588 cites W2090295661 @default.
• W2287302588 cites W2093976723 @default.
• W2287302588 cites W2095147658 @default.
• W2287302588 cites W2095369231 @default.
• W2287302588 cites W2112848244 @default.
• W2287302588 cites W2114032717 @default.
• W2287302588 cites W2121860798 @default.
• W2287302588 cites W2124085296 @default.
• W2287302588 cites W2135232043 @default.
• W2287302588 cites W2136293998 @default.
• W2287302588 cites W2149246998 @default.
• W2287302588 cites W2165597844 @default.
• W2287302588 cites W2171431480 @default.
• W2287302588 cites W2277794217 @default.
• W2287302588 doi "https://doi.org/10.3233/rnn-150591" @default.
• W2287302588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26890100" @default.
• W2287302588 hasPublicationYear "2016" @default.
• W2287302588 type Work @default.
• W2287302588 sameAs 2287302588 @default.
• W2287302588 citedByCount "2" @default.
• W2287302588 countsByYear W22873025882018 @default.
• W2287302588 countsByYear W22873025882019 @default.
• W2287302588 crossrefType "journal-article" @default.
• W2287302588 hasAuthorship W2287302588A5016525500 @default.
• W2287302588 hasAuthorship W2287302588A5063931891 @default.
• W2287302588 hasAuthorship W2287302588A5070387545 @default.
• W2287302588 hasAuthorship W2287302588A5072544096 @default.
• W2287302588 hasConcept C113045295 @default.
• W2287302588 hasConcept C126322002 @default.
• W2287302588 hasConcept C142724271 @default.
• W2287302588 hasConcept C169760540 @default.
• W2287302588 hasConcept C203014093 @default.
• W2287302588 hasConcept C2776914184 @default.
• W2287302588 hasConcept C2776925932 @default.
• W2287302588 hasConcept C2777682930 @default.
• W2287302588 hasConcept C2778271429 @default.
• W2287302588 hasConcept C2778402981 @default.
• W2287302588 hasConcept C2779134260 @default.
• W2287302588 hasConcept C2779540182 @default.
• W2287302588 hasConcept C2780394083 @default.
• W2287302588 hasConcept C2780942790 @default.
• W2287302588 hasConcept C2911091166 @default.
• W2287302588 hasConcept C529278444 @default.
• W2287302588 hasConcept C71924100 @default.
• W2287302588 hasConcept C86803240 @default.
• W2287302588 hasConcept C87753298 @default.

• next