FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2287337657> ?p ?o ?g. }

• W2287337657 abstract "Abstract The main clock located in the suprachiasmatic nucleus (SCN) regulates circadian rhythms in mammals. The SCN is composed of approximately twenty thousand heterogeneous self-oscillating neurons, that have intrinsic periods varying from 22 h to 28 h. They are coupled through neurotransmitters and neuropeptides to form a network and output a uniform periodic rhythm. Previous studies found that the heterogeneity of the neurons leads to attenuation of the circadian rhythm with strong cellular coupling. In the present study, we investigate the heterogeneity of the neurons and of the network in the condition of constant darkness. Interestingly, we found that the heterogeneity of weakly coupled neurons enables them to oscillate and strengthen the circadian rhythm. In addition, we found that the period of the SCN network increases with the increase of the degree of heterogeneity. As the network heterogeneity does not change the dynamics of the rhythm, our study shows that the heterogeneity of the neurons is vitally important for rhythm generation in weakly coupled systems, such as the SCN and it provides a new method to strengthen the circadian rhythm, as well as an alternative explanation for differences in free running periods between species in the absence of the daily cycle." @default.
• W2287337657 created "2016-06-24" @default.
• W2287337657 creator A5033777310 @default.
• W2287337657 creator A5033829704 @default.
• W2287337657 creator A5085910413 @default.
• W2287337657 creator A5091102395 @default.
• W2287337657 date "2016-02-22" @default.
• W2287337657 modified "2023-10-15" @default.
• W2287337657 title "Heterogeneity induces rhythms of weakly coupled circadian neurons" @default.
• W2287337657 cites W1952213740 @default.
• W2287337657 cites W1966592336 @default.
• W2287337657 cites W1969904423 @default.
• W2287337657 cites W1970130379 @default.
• W2287337657 cites W1972967454 @default.
• W2287337657 cites W1979032340 @default.
• W2287337657 cites W1987598332 @default.
• W2287337657 cites W1991021245 @default.
• W2287337657 cites W1991888613 @default.
• W2287337657 cites W2005758409 @default.
• W2287337657 cites W2008620264 @default.
• W2287337657 cites W2012066473 @default.
• W2287337657 cites W2017523111 @default.
• W2287337657 cites W2020340826 @default.
• W2287337657 cites W2030536090 @default.
• W2287337657 cites W2033917491 @default.
• W2287337657 cites W2042350655 @default.
• W2287337657 cites W2051483750 @default.
• W2287337657 cites W2058517022 @default.
• W2287337657 cites W2072299606 @default.
• W2287337657 cites W2072685125 @default.
• W2287337657 cites W2075406069 @default.
• W2287337657 cites W2082433800 @default.
• W2287337657 cites W2089876099 @default.
• W2287337657 cites W2093715084 @default.
• W2287337657 cites W2094426488 @default.
• W2287337657 cites W2098204603 @default.
• W2287337657 cites W2098615273 @default.
• W2287337657 cites W2104605616 @default.
• W2287337657 cites W2106394395 @default.
• W2287337657 cites W2107628671 @default.
• W2287337657 cites W2108130957 @default.
• W2287337657 cites W2111235220 @default.
• W2287337657 cites W2112090702 @default.
• W2287337657 cites W2117360286 @default.
• W2287337657 cites W2123103279 @default.
• W2287337657 cites W2127159598 @default.
• W2287337657 cites W2129332391 @default.
• W2287337657 cites W2131050167 @default.
• W2287337657 cites W2142214637 @default.
• W2287337657 cites W2149665977 @default.
• W2287337657 cites W2154473119 @default.
• W2287337657 cites W2171236970 @default.
• W2287337657 cites W2175171485 @default.
• W2287337657 cites W2238618065 @default.
• W2287337657 cites W2240116375 @default.
• W2287337657 cites W2483597142 @default.
• W2287337657 cites W3112761749 @default.
• W2287337657 doi "https://doi.org/10.1038/srep21412" @default.
• W2287337657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4761972" @default.
• W2287337657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26898574" @default.
• W2287337657 hasPublicationYear "2016" @default.
• W2287337657 type Work @default.
• W2287337657 sameAs 2287337657 @default.
• W2287337657 citedByCount "18" @default.
• W2287337657 countsByYear W22873376572016 @default.
• W2287337657 countsByYear W22873376572017 @default.
• W2287337657 countsByYear W22873376572018 @default.
• W2287337657 countsByYear W22873376572019 @default.
• W2287337657 countsByYear W22873376572020 @default.
• W2287337657 countsByYear W22873376572021 @default.
• W2287337657 countsByYear W22873376572022 @default.
• W2287337657 countsByYear W22873376572023 @default.
• W2287337657 crossrefType "journal-article" @default.
• W2287337657 hasAuthorship W2287337657A5033777310 @default.
• W2287337657 hasAuthorship W2287337657A5033829704 @default.
• W2287337657 hasAuthorship W2287337657A5085910413 @default.
• W2287337657 hasAuthorship W2287337657A5091102395 @default.
• W2287337657 hasBestOaLocation W22873376571 @default.
• W2287337657 hasConcept C118303440 @default.
• W2287337657 hasConcept C121332964 @default.
• W2287337657 hasConcept C121446783 @default.
• W2287337657 hasConcept C126322002 @default.
• W2287337657 hasConcept C135343436 @default.
• W2287337657 hasConcept C169760540 @default.
• W2287337657 hasConcept C170493617 @default.
• W2287337657 hasConcept C187765855 @default.
• W2287337657 hasConcept C201176492 @default.
• W2287337657 hasConcept C24890656 @default.
• W2287337657 hasConcept C2779027399 @default.
• W2287337657 hasConcept C2779317972 @default.
• W2287337657 hasConcept C2781291010 @default.
• W2287337657 hasConcept C54355233 @default.
• W2287337657 hasConcept C59822182 @default.
• W2287337657 hasConcept C71924100 @default.
• W2287337657 hasConcept C86803240 @default.
• W2287337657 hasConceptScore W2287337657C118303440 @default.
• W2287337657 hasConceptScore W2287337657C121332964 @default.
• W2287337657 hasConceptScore W2287337657C121446783 @default.
• W2287337657 hasConceptScore W2287337657C126322002 @default.
• W2287337657 hasConceptScore W2287337657C135343436 @default.

• next