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• W2287367445 abstract "Background: Despite intensive research efforts, the significance of microsatellite alterations in malignant tumors is not sufficiently understood. Since a possible causal connection between disease etiology and a germination mutation of the genes, involved in the mismatch repair mechanism, could be demostrated in patients with hereditary nonpolyposis colorectal cancer (HNPCC), the detection of microsatellite instabilities may be used to identify the so-called HNPCC syndrome. While the amount of proven microsatellite instabilities in sporadic tumor diseases is significantly lower than in the HNPCC syndrome, the mechanisms generating these instabilities have not been clarified yet. Their succesful measurement in serum, feces, urine, and sputum would extend the diagnostic repertory for tumor patients and possibly improve the early detection of neoplastic disease or its recurrence. Results: In this thesis, a PCR-based method was established for the analysis of microsatellite alterations in tumor specimens and serum samples. Three microsatellite markers were employed, including AR, ACTBP2, and UT762. The DNA of tumors and serum was analyzed and compared with the DNA of lymphocytes. Specimens of 43 patients with bronchial carcinoma (16 small cell lung carcinoma (SCLC), 27 non-small cell lung carcinoma (NSCLC)) were examined. In 5 of the patients with SCLC (31%) and in 9 of those with NSCLC (33%) a microsatellite instability or a loss of heterozygosity (LOH) was demonstrated in at least one microsatellite locus. The controls, which included samples of serum and lymphocytes of 10 healthy volunteers, did not show any microsatellite alterations. Outlook: The still poor prognosis of patients with bronchial carcinoma warrants further development of sensitive and reliable methods to improve early detection. Beyond this study, further microsatellite markers need to be tested in a sufficient number of patients with respect to sensitivity and specificity of tumor diagnosis. In addition, the prognostic significance of microsatellite alterations in tumor patients requires further investigation." @default.
• W2287367445 created "2016-06-24" @default.
• W2287367445 creator A5029423634 @default.
• W2287367445 date "1999-10-20" @default.
• W2287367445 modified "2023-09-25" @default.
• W2287367445 title "Mikrosatellitenalterationen in der Serum-DNA bei Patienten mit Bronchialkarzinom" @default.
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• W2287367445 doi "https://doi.org/10.18452/14422" @default.
• W2287367445 hasPublicationYear "1999" @default.
• W2287367445 type Work @default.
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• W2287367445 crossrefType "dissertation" @default.
• W2287367445 hasAuthorship W2287367445A5029423634 @default.
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