Matches in SemOpenAlex for { <https://semopenalex.org/work/W2287369493> ?p ?o ?g. }
- W2287369493 endingPage "1912" @default.
- W2287369493 startingPage "1903" @default.
- W2287369493 abstract "In the adult brain, neural stem cells (NSCs) can self-renew and generate all neural lineage types, and they persist in the sub-granular zone (SGZ) of the hippocampus and the sub-ventricular zone (SVZ) of the cortex. Here, we show that dietary-supplemented - magnesium-L-threonate (MgT), a novel magnesium compound designed to elevate brain magnesium regulates the NSC pool in the adult hippocampus. We found that administration of both short- and long-term regimens of MgT, increased the number of hippocampal NSCs. We demonstrated that in young mice, dietary supplementation with MgT significantly enhanced NSC proliferation in the SGZ. Importantly, in aged mice that underwent long-term (12-month) supplementation with MgT, MgT did not deplete the hippocampal NSC reservoir but rather curtailed the age-associated decline in NSC proliferation. We further established an association between extracellular magnesium concentrations and NSC self-renewal in vitro by demonstrating that elevated Mg2+ concentrations can maintain or increase the number of cultured hippocampal NSCs. Our study also suggests that key signaling pathways for cell growth and proliferation may be candidate targets for Mg2+'s effects on NSC self-renewal. J. Cell. Physiol. 231: 1903–1912, 2016. © 2016 Wiley Periodicals, Inc." @default.
- W2287369493 created "2016-06-24" @default.
- W2287369493 creator A5014661502 @default.
- W2287369493 creator A5015325206 @default.
- W2287369493 creator A5025109126 @default.
- W2287369493 creator A5032289331 @default.
- W2287369493 creator A5059788513 @default.
- W2287369493 creator A5076904989 @default.
- W2287369493 creator A5081310064 @default.
- W2287369493 date "2016-02-02" @default.
- W2287369493 modified "2023-09-28" @default.
- W2287369493 title "Elevation of Brain Magnesium Potentiates Neural Stem Cell Proliferation in the Hippocampus of Young and Aged Mice" @default.
- W2287369493 cites W1507173423 @default.
- W2287369493 cites W1561090959 @default.
- W2287369493 cites W1775250759 @default.
- W2287369493 cites W1963940970 @default.
- W2287369493 cites W1967490301 @default.
- W2287369493 cites W1986346910 @default.
- W2287369493 cites W1994344006 @default.
- W2287369493 cites W1995168386 @default.
- W2287369493 cites W1997568797 @default.
- W2287369493 cites W1998288051 @default.
- W2287369493 cites W1998347917 @default.
- W2287369493 cites W2009364099 @default.
- W2287369493 cites W2011580597 @default.
- W2287369493 cites W2014490965 @default.
- W2287369493 cites W2016500868 @default.
- W2287369493 cites W2030613337 @default.
- W2287369493 cites W2031432617 @default.
- W2287369493 cites W2034603487 @default.
- W2287369493 cites W2035129561 @default.
- W2287369493 cites W2036678630 @default.
- W2287369493 cites W2046157151 @default.
- W2287369493 cites W2046381759 @default.
- W2287369493 cites W2048566307 @default.
- W2287369493 cites W2048711819 @default.
- W2287369493 cites W2050938473 @default.
- W2287369493 cites W2051173215 @default.
- W2287369493 cites W2057608998 @default.
- W2287369493 cites W2057929164 @default.
- W2287369493 cites W2069785065 @default.
- W2287369493 cites W2076681174 @default.
- W2287369493 cites W2085283151 @default.
- W2287369493 cites W2088961594 @default.
- W2287369493 cites W2089532564 @default.
- W2287369493 cites W2094840655 @default.
- W2287369493 cites W2095516746 @default.
- W2287369493 cites W2097408153 @default.
- W2287369493 cites W2102366043 @default.
- W2287369493 cites W2102801447 @default.
- W2287369493 cites W2105089471 @default.
- W2287369493 cites W2108432043 @default.
- W2287369493 cites W2109081919 @default.
- W2287369493 cites W2111115992 @default.
- W2287369493 cites W2111888363 @default.
- W2287369493 cites W2119754857 @default.
- W2287369493 cites W2120485135 @default.
- W2287369493 cites W2121586624 @default.
- W2287369493 cites W2121972943 @default.
- W2287369493 cites W2124506047 @default.
- W2287369493 cites W2125095601 @default.
- W2287369493 cites W2128008807 @default.
- W2287369493 cites W2128367294 @default.
- W2287369493 cites W2131414754 @default.
- W2287369493 cites W2135046848 @default.
- W2287369493 cites W2144186309 @default.
- W2287369493 cites W2145796722 @default.
- W2287369493 cites W2150583853 @default.
- W2287369493 cites W2165550047 @default.
- W2287369493 cites W2168738523 @default.
- W2287369493 cites W2172297511 @default.
- W2287369493 cites W4213247425 @default.
- W2287369493 doi "https://doi.org/10.1002/jcp.25306" @default.
- W2287369493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26754806" @default.
- W2287369493 hasPublicationYear "2016" @default.
- W2287369493 type Work @default.
- W2287369493 sameAs 2287369493 @default.
- W2287369493 citedByCount "11" @default.
- W2287369493 countsByYear W22873694932018 @default.
- W2287369493 countsByYear W22873694932019 @default.
- W2287369493 countsByYear W22873694932020 @default.
- W2287369493 countsByYear W22873694932021 @default.
- W2287369493 countsByYear W22873694932022 @default.
- W2287369493 countsByYear W22873694932023 @default.
- W2287369493 crossrefType "journal-article" @default.
- W2287369493 hasAuthorship W2287369493A5014661502 @default.
- W2287369493 hasAuthorship W2287369493A5015325206 @default.
- W2287369493 hasAuthorship W2287369493A5025109126 @default.
- W2287369493 hasAuthorship W2287369493A5032289331 @default.
- W2287369493 hasAuthorship W2287369493A5059788513 @default.
- W2287369493 hasAuthorship W2287369493A5076904989 @default.
- W2287369493 hasAuthorship W2287369493A5081310064 @default.
- W2287369493 hasConcept C126322002 @default.
- W2287369493 hasConcept C134018914 @default.
- W2287369493 hasConcept C136834591 @default.
- W2287369493 hasConcept C148762608 @default.
- W2287369493 hasConcept C1491633281 @default.
- W2287369493 hasConcept C169760540 @default.