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• W2287402019 endingPage "2040" @default.
• W2287402019 startingPage "2033" @default.
• W2287402019 abstract "The independent and combined effects of exercise training and hormone replacement therapy (HRT) on body composition, fat distribution, glucose tolerance, and insulin action were studied in postmenopausal women, aged 68 ± 5 yr, assigned to control ( n = 19), exercise ( n = 18), HRT ( n = 15), and exercise + HRT ( n = 16) groups. The exercise consisted of 2 mo of flexibility exercises followed by 9 mo of endurance exercise. HRT was conjugated estrogens 0.625 mg/day and trimonthly medroxyprogesterone acetate 5 mg/day for 13 days. Total and regional body composition were measured by dual-energy X-ray absorptiometry. Serum glucose and insulin responses were measured during a 2-h oral glucose tolerance test. There were significant main effects of exercise on reductions in total and regional (trunk, arms, legs) fat mass, increase in leg fat-free mass, and improvements in glucose tolerance and insulin action. There were significant main effects of HRT on the reduction of total fat mass (HRT, −3.0 ± 4.0 kg; no HRT, −1.3 ± 2.6 kg), with a strong trend for reductions in trunk and leg fat mass (both P = 0.07). There was also a significant improvement in insulin action in response to HRT. These results suggest that there are independent and additive effects of exercise training and HRT on the reduction in fat mass and improvement in insulin action in postmenopausal women; the effect of HRT on insulin action may be mediated, in part, through changes in central adiposity." @default.
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• W2287402019 date "2001-06-01" @default.
• W2287402019 modified "2023-10-15" @default.
• W2287402019 title "Effects of HRT and exercise training on insulin action, glucose tolerance, and body composition in older women" @default.
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• W2287402019 doi "https://doi.org/10.1152/jappl.2001.90.6.2033" @default.
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