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- W2287471504 abstract "Objective To evaluate the modulation of RhoA/Rho kinase (ROCK) signaling pathway,a small Rho GTPase that is considered as an important modulator in inflammatory responses,on Toll-like receptor-2 mediated chemokine secretion in fibroblast-like synoviocytes (FLS)from rheumatoid arthritis (RA) patients.Methods The RhoA activity was measured by a pull-down assay.And the ROCK activity was assessed by Western blot.The secretion of chemokines was measured by ELISA (enzyme-linked immunosorbent assay).MTT test was used to detect the cellular viability.Results The stimulation of peptidoglycan(PG,5 mg/L) increased the levels of IL-8 (interleukin-8),RANTES (regulated upon activation normal T cell expressed & secreted) and MCP-2 (monocyte chemotactic protein-2)and boosted the activities of RhoA and ROCK versus the unstimulated RA FLS.And these effects of PG were suppressed by anti-TLR-2 monoclonal antibody.Inhibition of RhoA and ROCK with a specific inhibitor inhibited the secretion of IL-8,RANTES and MCP-2 in PG-induced RA FLS.Conclusion The present study provides novel evidence that the RhoA/ROCK signal pathway modulates the TLR-2-mediated secretion of chemokines in RA FLS.It suggests that the inhibition of RhoA/ROCK may be a new therapeutic approach for RA.Key words: Rheumatoid arthritis; Fibroblast like synoviocytes; Chemokine; Rho; Toll like receptor" @default.
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- W2287471504 date "2011-03-22" @default.
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- W2287471504 title "[Modulation of RhoA/ROCK pathway on TLR-2 ligand-induced chemokine secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis]." @default.
- W2287471504 doi "https://doi.org/10.3760/cma.j.issn.0376-2491.2011.11.008" @default.
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