FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2287492044> ?p ?o ?g. }

• W2287492044 endingPage "e0127764" @default.
• W2287492044 startingPage "e0127764" @default.
• W2287492044 abstract "Temperature is fundamentally important to all biological functions including synaptic glutamate release. Vagal afferents from the solitary tract (ST) synapse on second order neurons in the nucleus of the solitary tract, and glutamate release at this first central synapse controls autonomic reflex function. Expression of the temperature-sensitive Transient Receptor Potential Vanilloid Type 1 receptor separates ST afferents into C-fibers (TRPV1+) and A-fibers (TRPV1-). Action potential-evoked glutamate release is similar between C- and A-fiber afferents, but TRPV1 expression facilitates a second form of synaptic glutamate release in C-fibers by promoting substantially more spontaneous glutamate release. The influence of temperature on different forms of glutamate release is not well understood. Here we tested how temperature impacts the generation of evoked and spontaneous release of glutamate and its relation to TRPV1 expression. In horizontal brainstem slices of rats, activation of ST primary afferents generated synchronous evoked glutamate release (ST-eEPSCs) at constant latency whose amplitude reflects the probability of evoked glutamate release. The frequency of spontaneous EPSCs in these same neurons measured the probability of spontaneous glutamate release. We measured both forms of glutamate from each neuron during ramp changes in bath temperature of 4-5 °C. Spontaneous glutamate release from TRPV1+ closely tracked with these thermal changes indicating changes in the probability of spontaneous glutamate release. In the same neurons, temperature changed axon conduction registered as latency shifts but ST-eEPSC amplitudes were constant and independent of TRPV1 expression. These data indicate that TRPV1-operated glutamate release is independent of action potential-evoked glutamate release in the same neurons. Together, these support the hypothesis that evoked and spontaneous glutamate release originate from two pools of vesicles that are independently modulated and are distinct processes." @default.
• W2287492044 created "2016-06-24" @default.
• W2287492044 creator A5013733361 @default.
• W2287492044 creator A5036290584 @default.
• W2287492044 creator A5049808747 @default.
• W2287492044 creator A5086540877 @default.
• W2287492044 date "2015-05-20" @default.
• W2287492044 modified "2023-09-24" @default.
• W2287492044 title "Temperature Differentially Facilitates Spontaneous but Not Evoked Glutamate Release from Cranial Visceral Primary Afferents" @default.
• W2287492044 cites W1531283035 @default.
• W2287492044 cites W1669110353 @default.
• W2287492044 cites W1883044208 @default.
• W2287492044 cites W1923600385 @default.
• W2287492044 cites W1964779574 @default.
• W2287492044 cites W1980010331 @default.
• W2287492044 cites W1981413880 @default.
• W2287492044 cites W2004297570 @default.
• W2287492044 cites W2008048120 @default.
• W2287492044 cites W2013948413 @default.
• W2287492044 cites W2018278434 @default.
• W2287492044 cites W2025761537 @default.
• W2287492044 cites W2033866317 @default.
• W2287492044 cites W2035387654 @default.
• W2287492044 cites W2038193286 @default.
• W2287492044 cites W2041165725 @default.
• W2287492044 cites W2052237161 @default.
• W2287492044 cites W2056725495 @default.
• W2287492044 cites W2061040353 @default.
• W2287492044 cites W2063286825 @default.
• W2287492044 cites W2065359945 @default.
• W2287492044 cites W2068032188 @default.
• W2287492044 cites W2077212686 @default.
• W2287492044 cites W2094694532 @default.
• W2287492044 cites W2096681544 @default.
• W2287492044 cites W2102492718 @default.
• W2287492044 cites W2111467441 @default.
• W2287492044 cites W2124418433 @default.
• W2287492044 cites W2132634436 @default.
• W2287492044 cites W2135769863 @default.
• W2287492044 cites W2142657247 @default.
• W2287492044 cites W2147496208 @default.
• W2287492044 cites W2150142099 @default.
• W2287492044 cites W2153309256 @default.
• W2287492044 cites W2169177908 @default.
• W2287492044 cites W2181484766 @default.
• W2287492044 cites W2293003331 @default.
• W2287492044 cites W2321644475 @default.
• W2287492044 cites W2329826872 @default.
• W2287492044 cites W2408807018 @default.
• W2287492044 cites W2410841626 @default.
• W2287492044 doi "https://doi.org/10.1371/journal.pone.0127764" @default.
• W2287492044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4439140" @default.
• W2287492044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25992717" @default.
• W2287492044 hasPublicationYear "2015" @default.
• W2287492044 type Work @default.
• W2287492044 sameAs 2287492044 @default.
• W2287492044 citedByCount "9" @default.
• W2287492044 countsByYear W22874920442016 @default.
• W2287492044 countsByYear W22874920442017 @default.
• W2287492044 countsByYear W22874920442018 @default.
• W2287492044 countsByYear W22874920442019 @default.
• W2287492044 countsByYear W22874920442021 @default.
• W2287492044 crossrefType "journal-article" @default.
• W2287492044 hasAuthorship W2287492044A5013733361 @default.
• W2287492044 hasAuthorship W2287492044A5036290584 @default.
• W2287492044 hasAuthorship W2287492044A5049808747 @default.
• W2287492044 hasAuthorship W2287492044A5086540877 @default.
• W2287492044 hasBestOaLocation W22874920441 @default.
• W2287492044 hasConcept C12554922 @default.
• W2287492044 hasConcept C127445978 @default.
• W2287492044 hasConcept C155164980 @default.
• W2287492044 hasConcept C160145004 @default.
• W2287492044 hasConcept C169760540 @default.
• W2287492044 hasConcept C170493617 @default.
• W2287492044 hasConcept C185592680 @default.
• W2287492044 hasConcept C49051014 @default.
• W2287492044 hasConcept C55493867 @default.
• W2287492044 hasConcept C61174792 @default.
• W2287492044 hasConcept C86803240 @default.
• W2287492044 hasConceptScore W2287492044C12554922 @default.
• W2287492044 hasConceptScore W2287492044C127445978 @default.
• W2287492044 hasConceptScore W2287492044C155164980 @default.
• W2287492044 hasConceptScore W2287492044C160145004 @default.
• W2287492044 hasConceptScore W2287492044C169760540 @default.
• W2287492044 hasConceptScore W2287492044C170493617 @default.
• W2287492044 hasConceptScore W2287492044C185592680 @default.
• W2287492044 hasConceptScore W2287492044C49051014 @default.
• W2287492044 hasConceptScore W2287492044C55493867 @default.
• W2287492044 hasConceptScore W2287492044C61174792 @default.
• W2287492044 hasConceptScore W2287492044C86803240 @default.
• W2287492044 hasIssue "5" @default.
• W2287492044 hasLocation W22874920441 @default.
• W2287492044 hasLocation W22874920442 @default.
• W2287492044 hasLocation W22874920443 @default.
• W2287492044 hasLocation W22874920444 @default.
• W2287492044 hasLocation W22874920445 @default.
• W2287492044 hasOpenAccess W2287492044 @default.
• W2287492044 hasPrimaryLocation W22874920441 @default.

• next