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- W2287593267 abstract "There is no effective drug to treat EV71 infection yet. Traditional Chinese herbs are great resources for novel antiviral compounds. Here we showed that Oblongifolin M (OM), an active compound isolated from Garcinia oblongifolia, potently inhibited EV71 infection in a dose dependent manner. To identify its potential effectors in the host cells, we successfully identified 18 proteins from 52 differentially expressed spots by comparative proteomics studies. Further studies showed that knockdown of ERp57 inhibited viral replication through downregulating viral IRES (internal ribosome entry site) activities, whereas ectopic expression of ERp57 increased IRES activity and partly rescued the inhibitory effects of OM on viral replication. We demonstrated that OM is an effective antiviral agent; and that ERp57 is one of its cellular effectors against EV71 infection." @default.
- W2287593267 created "2016-06-24" @default.
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- W2287593267 date "2016-02-01" @default.
- W2287593267 modified "2023-10-17" @default.
- W2287593267 title "Oblongifolin M, an active compound isolated from a Chinese medical herb <i>Garcinia oblongifolia</i>, potently inhibits enterovirus 71 reproduction through downregulation of ERp57" @default.
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- W2287593267 doi "https://doi.org/10.18632/oncotarget.7122" @default.
- W2287593267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4891005" @default.
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