FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2287594509> ?p ?o ?g. }

• W2287594509 endingPage "e1682" @default.
• W2287594509 startingPage "e1682" @default.
• W2287594509 abstract "MicoRNAs (miRNAs), usually as gene regulators, participate in various biological processes, including stress responses. The hypothalamus–pituitary–adrenal axis (HPA axis) is an important pathway in regulating stress response. Although the mechanism that HPA axis regulates stress response has been basically revealed, the knowledge that miRNAs regulate stress response within HPA axis, still remains poor. The object of this study was to investigate the miRNAs in the pituitary and adrenal cortex that regulate chronic stress response with high-throughput sequencing. The pituitary and adrenal cortex of beagles and Chinese Field dogs (CFD) from a stress exposure group (including beagle pituitary 1 (BP1), CFD pituitary 1 (CFDP1), beagle adrenal cortex 1 (BAC1), CFD adrenal cortex 1 (CFDAC1)) and a control group (including beagle pituitary 2 (BP2), CFD pituitary 2 (CFDP2), beagle adrenal cortex 2 (BAC2), CFD adrenal cortex 2 (CFDAC2)), were selected for miRNA-seq comparisons. Comparisons, that were made in pituitary (including BP1 vs. BP2, CFDP1 vs. CFDP2, BP1 vs. CFDP1 and BP2 vs. CFDP2) and adrenal cortex (including BAC1 vs. BAC2, CFDAC1 vs. CFDAC2, BAC1 vs. CFDAC1 and BAC2 vs. CFDAC2), showed that a total of 39 and 18 common differentially expressed miRNAs (DE-miRNAs) (Total read counts > 1,000, Fold change > 2 & p -value < 0.001), that shared in at least two pituitary comparisons and at least two adrenal cortex comparisons, were detected separately. These identified DE-miRNAs were predicted for target genes, thus resulting in 3,959 and 4,010 target genes in pituitary and adrenal cortex, respectively. Further, 105 and 10 differentially expressed genes (DEGs) (Fold change > 2 & p -value < 0.05) from those target genes in pituitary and adrenal cortex were obtained separately, in combination with our previous corresponding transcriptome study. Meanwhile, in line with that miRNAs usually negatively regulated their target genes and the dual luciferase reporter assay, we finally identified cfa-miR-205 might play an important role by upregulating MMD in pituitary and hippocampus, thus enhancing the immune response, under chronic stress exposure. Our results shed light on the miRNA expression profiles in the pituitary and adrenal cortex with and without chronic stress exposure, and provide a new insight into miR-205 with its feasible role in regulating chronic stress in the pituitary and hippocampus through targeting MMD ." @default.
• W2287594509 created "2016-06-24" @default.
• W2287594509 creator A5017274582 @default.
• W2287594509 creator A5017669233 @default.
• W2287594509 creator A5026543951 @default.
• W2287594509 creator A5031913604 @default.
• W2287594509 creator A5055511325 @default.
• W2287594509 creator A5077280654 @default.
• W2287594509 date "2016-02-18" @default.
• W2287594509 modified "2023-10-17" @default.
• W2287594509 title "Comparison of miRNA expression profiles in pituitary–adrenal axis between Beagle and Chinese Field dogs after chronic stress exposure" @default.
• W2287594509 cites W144423133 @default.
• W2287594509 cites W1561463658 @default.
• W2287594509 cites W1582667708 @default.
• W2287594509 cites W1607762612 @default.
• W2287594509 cites W166886560 @default.
• W2287594509 cites W1989841881 @default.
• W2287594509 cites W1994298012 @default.
• W2287594509 cites W2001863509 @default.
• W2287594509 cites W2002686613 @default.
• W2287594509 cites W2015858554 @default.
• W2287594509 cites W2028776429 @default.
• W2287594509 cites W2031841514 @default.
• W2287594509 cites W2040766015 @default.
• W2287594509 cites W2045470216 @default.
• W2287594509 cites W2046401180 @default.
• W2287594509 cites W2071704166 @default.
• W2287594509 cites W2086817773 @default.
• W2287594509 cites W2100358595 @default.
• W2287594509 cites W2112262501 @default.
• W2287594509 cites W2114570899 @default.
• W2287594509 cites W2119034410 @default.
• W2287594509 cites W2124985265 @default.
• W2287594509 cites W2130305733 @default.
• W2287594509 cites W2130388134 @default.
• W2287594509 cites W2130950392 @default.
• W2287594509 cites W2148477576 @default.
• W2287594509 cites W2152327613 @default.
• W2287594509 cites W2164533019 @default.
• W2287594509 cites W2171025917 @default.
• W2287594509 cites W2197983246 @default.
• W2287594509 cites W2203561597 @default.
• W2287594509 cites W331284098 @default.
• W2287594509 doi "https://doi.org/10.7717/peerj.1682" @default.
• W2287594509 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4768678" @default.
• W2287594509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26925320" @default.
• W2287594509 hasPublicationYear "2016" @default.
• W2287594509 type Work @default.
• W2287594509 sameAs 2287594509 @default.
• W2287594509 citedByCount "3" @default.
• W2287594509 countsByYear W22875945092018 @default.
• W2287594509 countsByYear W22875945092023 @default.
• W2287594509 crossrefType "journal-article" @default.
• W2287594509 hasAuthorship W2287594509A5017274582 @default.
• W2287594509 hasAuthorship W2287594509A5017669233 @default.
• W2287594509 hasAuthorship W2287594509A5026543951 @default.
• W2287594509 hasAuthorship W2287594509A5031913604 @default.
• W2287594509 hasAuthorship W2287594509A5055511325 @default.
• W2287594509 hasAuthorship W2287594509A5077280654 @default.
• W2287594509 hasBestOaLocation W22875945091 @default.
• W2287594509 hasConcept C126322002 @default.
• W2287594509 hasConcept C134018914 @default.
• W2287594509 hasConcept C169760540 @default.
• W2287594509 hasConcept C2776820430 @default.
• W2287594509 hasConcept C2777348757 @default.
• W2287594509 hasConcept C2777977426 @default.
• W2287594509 hasConcept C2779029589 @default.
• W2287594509 hasConcept C2779146795 @default.
• W2287594509 hasConcept C71315377 @default.
• W2287594509 hasConcept C71924100 @default.
• W2287594509 hasConcept C86803240 @default.
• W2287594509 hasConceptScore W2287594509C126322002 @default.
• W2287594509 hasConceptScore W2287594509C134018914 @default.
• W2287594509 hasConceptScore W2287594509C169760540 @default.
• W2287594509 hasConceptScore W2287594509C2776820430 @default.
• W2287594509 hasConceptScore W2287594509C2777348757 @default.
• W2287594509 hasConceptScore W2287594509C2777977426 @default.
• W2287594509 hasConceptScore W2287594509C2779029589 @default.
• W2287594509 hasConceptScore W2287594509C2779146795 @default.
• W2287594509 hasConceptScore W2287594509C71315377 @default.
• W2287594509 hasConceptScore W2287594509C71924100 @default.
• W2287594509 hasConceptScore W2287594509C86803240 @default.
• W2287594509 hasFunder F4320321001 @default.
• W2287594509 hasLocation W22875945091 @default.
• W2287594509 hasLocation W22875945092 @default.
• W2287594509 hasLocation W22875945093 @default.
• W2287594509 hasLocation W22875945094 @default.
• W2287594509 hasLocation W22875945095 @default.
• W2287594509 hasOpenAccess W2287594509 @default.
• W2287594509 hasPrimaryLocation W22875945091 @default.
• W2287594509 hasRelatedWork W1525008282 @default.
• W2287594509 hasRelatedWork W1591772104 @default.
• W2287594509 hasRelatedWork W2039503738 @default.
• W2287594509 hasRelatedWork W2048183677 @default.
• W2287594509 hasRelatedWork W2072230422 @default.
• W2287594509 hasRelatedWork W2129189638 @default.
• W2287594509 hasRelatedWork W2149854914 @default.
• W2287594509 hasRelatedWork W2417765753 @default.

• next