FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2287618675> ?p ?o ?g. }

• W2287618675 endingPage "22" @default.
• W2287618675 startingPage "22" @default.
• W2287618675 abstract "Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on energy metabolism and insulin sensitivity. Besides its antiobese and antidiabetic activity, FGF21 also possesses the protective effects against atherosclerosis. Circulating levels of FGF21 are elevated in patients with atherosclerosis, macrovascular and microvascular complications of diabetes, possibly due to a compensatory upregulation. In apolipoprotein E-deficient mice, formation of atherosclerotic plaques is exacerbated by genetic depletion of FGF21, but is attenuated upon replenishment with recombinant FGF21. However, the blood vessel is not the direct target of FGF21, and the antiatherosclerotic activity of FGF21 is attributed to its actions in adipose tissues and liver. In adipocytes, FGF21 promotes secretion of adiponectin, which in turn acts directly on blood vessels to reduce endothelial dysfunction, inhibit proliferation of smooth muscle cells and block conversion of macrophages to foam cells. Furthermore, FGF21 suppresses cholesterol biosynthesis and attenuates hypercholesterolemia by inhibiting the transcription factor sterol regulatory element-binding protein-2 in hepatocytes. The effects of FGF21 on elevation of adiponectin and reduction of hypercholesterolemia are also observed in a phase-1b clinical trial in patients with obesity and diabetes. Therefore, FGF21 exerts its protection against atherosclerosis by fine-tuning the interorgan crosstalk between liver, brain, adipose tissue, and blood vessels. Keywords: Adiponectin; Fibroblast growth factor 21; Hypercholesterolemia; Metabolic syndrome; Vascular diseases" @default.
• W2287618675 created "2016-06-24" @default.
• W2287618675 creator A5031014820 @default.
• W2287618675 creator A5047310137 @default.
• W2287618675 creator A5090327012 @default.
• W2287618675 date "2016-01-01" @default.
• W2287618675 modified "2023-10-14" @default.
• W2287618675 title "Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk" @default.
• W2287618675 cites W1516131201 @default.
• W2287618675 cites W152959201 @default.
• W2287618675 cites W1553825897 @default.
• W2287618675 cites W1964814161 @default.
• W2287618675 cites W1968091833 @default.
• W2287618675 cites W1971542373 @default.
• W2287618675 cites W1977123721 @default.
• W2287618675 cites W1978039711 @default.
• W2287618675 cites W1981261500 @default.
• W2287618675 cites W1983477298 @default.
• W2287618675 cites W1993235686 @default.
• W2287618675 cites W1999249055 @default.
• W2287618675 cites W2000665430 @default.
• W2287618675 cites W2009616432 @default.
• W2287618675 cites W2011712684 @default.
• W2287618675 cites W2012853495 @default.
• W2287618675 cites W2021308161 @default.
• W2287618675 cites W2022287325 @default.
• W2287618675 cites W2025139842 @default.
• W2287618675 cites W2029413179 @default.
• W2287618675 cites W2032787352 @default.
• W2287618675 cites W2043935886 @default.
• W2287618675 cites W2047726905 @default.
• W2287618675 cites W2048411348 @default.
• W2287618675 cites W2060734703 @default.
• W2287618675 cites W2062842771 @default.
• W2287618675 cites W2069497802 @default.
• W2287618675 cites W2074337024 @default.
• W2287618675 cites W2080977866 @default.
• W2287618675 cites W2082930819 @default.
• W2287618675 cites W2088503595 @default.
• W2287618675 cites W2089807028 @default.
• W2287618675 cites W2089817491 @default.
• W2287618675 cites W2100232436 @default.
• W2287618675 cites W2100474316 @default.
• W2287618675 cites W2101962482 @default.
• W2287618675 cites W2106745402 @default.
• W2287618675 cites W2110534048 @default.
• W2287618675 cites W2111653877 @default.
• W2287618675 cites W2118723490 @default.
• W2287618675 cites W2119331212 @default.
• W2287618675 cites W2120320286 @default.
• W2287618675 cites W2121049950 @default.
• W2287618675 cites W2130700195 @default.
• W2287618675 cites W2131622156 @default.
• W2287618675 cites W2134403068 @default.
• W2287618675 cites W2134810803 @default.
• W2287618675 cites W2139801418 @default.
• W2287618675 cites W2141124825 @default.
• W2287618675 cites W2145044799 @default.
• W2287618675 cites W2145142659 @default.
• W2287618675 cites W2146517905 @default.
• W2287618675 cites W2146544786 @default.
• W2287618675 cites W2147029239 @default.
• W2287618675 cites W2147734839 @default.
• W2287618675 cites W2155763704 @default.
• W2287618675 cites W2158477352 @default.
• W2287618675 cites W2160488327 @default.
• W2287618675 cites W2162023168 @default.
• W2287618675 cites W2166878182 @default.
• W2287618675 cites W2171151924 @default.
• W2287618675 cites W2184009762 @default.
• W2287618675 cites W31735925 @default.
• W2287618675 cites W4252021281 @default.
• W2287618675 doi "https://doi.org/10.4093/dmj.2016.40.1.22" @default.
• W2287618675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4768047" @default.
• W2287618675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26912152" @default.
• W2287618675 hasPublicationYear "2016" @default.
• W2287618675 type Work @default.
• W2287618675 sameAs 2287618675 @default.
• W2287618675 citedByCount "38" @default.
• W2287618675 countsByYear W22876186752016 @default.
• W2287618675 countsByYear W22876186752017 @default.
• W2287618675 countsByYear W22876186752018 @default.
• W2287618675 countsByYear W22876186752019 @default.
• W2287618675 countsByYear W22876186752020 @default.
• W2287618675 countsByYear W22876186752021 @default.
• W2287618675 countsByYear W22876186752022 @default.
• W2287618675 countsByYear W22876186752023 @default.
• W2287618675 crossrefType "journal-article" @default.
• W2287618675 hasAuthorship W2287618675A5031014820 @default.
• W2287618675 hasAuthorship W2287618675A5047310137 @default.
• W2287618675 hasAuthorship W2287618675A5090327012 @default.
• W2287618675 hasBestOaLocation W22876186751 @default.
• W2287618675 hasConcept C104317684 @default.
• W2287618675 hasConcept C106646824 @default.
• W2287618675 hasConcept C126322002 @default.
• W2287618675 hasConcept C127561419 @default.
• W2287618675 hasConcept C134018914 @default.
• W2287618675 hasConcept C170493617 @default.

• next