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- W2287657295 abstract "Nitrendipine an anti hypertensive drug which is practically insoluble in water. But water insolubility and the less bioavailability are the limitations of its effective use clinically. The present investigation aims to study the effect of various solvent on the modifications of Nitrendipine. The different forms of crystals were prepared by using various solvents such as acetone, benzene, methanol and blends of methanol with polyvinyl pyrrollidone (PVP-K30) and polyethylene glycol(PEG-4000).The prepared crystals were characterized by different physico-chemical techniques such as melting point, solubility, spectroscopic analysis and dissolution. The results indicate that the crystals obtained from different solvents exhibited different physiochemical characters. In conclusion, the crystals prepared from benzene, PVP-K30 and PEG-4000 shows higher dissolution rate would result in an improved bio-availability" @default.
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- W2287657295 date "2008-09-28" @default.
- W2287657295 modified "2023-09-26" @default.
- W2287657295 title "Polymorphism: A Dissolution Rate Enhancement Technique of Nitrendipine" @default.
- W2287657295 hasPublicationYear "2008" @default.
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