Matches in SemOpenAlex for { <https://semopenalex.org/work/W2287677104> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2287677104 endingPage "7" @default.
- W2287677104 startingPage "93" @default.
- W2287677104 abstract "PR domain zinc finger protein 14 (PRDM14) is an important member of the PRDM family, PRDM14 plays a key role in the maintenance of cell integrity and differentiation, growth and apoptosis of the cell. It also plays an critical role in the formation of primordial germ cells, the maintenance of the totipotency of stem cells and the formation of tissues and organs. PRDM14 bears a single PR domain and six tandemly repeated zinc fingers, which is involved in the process of the deacetylation and methylation of the histone, and is involved in the formation of tumor trough the change level of methylation in the promoter region. The abnormal methylation of PRDM14 can change the chromatin structure, DNA conformation and the interaction mode of DNA and protein, it can suppress transcription and expression of the gene, which caused the occurrence, development and metastasis of tumor. The research progress of PRDM14 is reviewed based on the relevant literatures published in China and abroad. 正性调节区锌指蛋白14（PR domain zinc finger protein 14, PRDM14）是PRDM家族中的重要成员，PRDM14基因对维持细胞的完整性和控制细胞的分化、生长及凋亡起着关键作用，在原始生殖细胞的形成、干细胞全能性的维持和其他组织器官的形成中都发挥了重要作用。PRDM14具有1个PR结构域和6个锌指结构，PRDM14参与了组蛋白的去乙酰化及甲基化过程，通过启动子区甲基化水平的改变参与肿瘤的形成。PRDM14异常甲基化能够引起染色质结构、DNA构象及DNA与蛋白质作用方式的改变，使基因的转录和表达受抑制，这些改变引起了肿瘤的发生、发展及转移。本文根据国内外发表的相关文献对PRDM14的研究现状进行综述。." @default.
- W2287677104 created "2016-06-24" @default.
- W2287677104 creator A5039226759 @default.
- W2287677104 creator A5056994271 @default.
- W2287677104 date "2016-02-01" @default.
- W2287677104 modified "2023-09-27" @default.
- W2287677104 title "[Research Progress of PR Domain Zinc Finger Protein 14]." @default.
- W2287677104 cites W1185105108 @default.
- W2287677104 cites W1576675950 @default.
- W2287677104 cites W1608555175 @default.
- W2287677104 cites W1976709037 @default.
- W2287677104 cites W1978358191 @default.
- W2287677104 cites W1983096620 @default.
- W2287677104 cites W1993441227 @default.
- W2287677104 cites W1993745480 @default.
- W2287677104 cites W2004618496 @default.
- W2287677104 cites W2012443495 @default.
- W2287677104 cites W2015414753 @default.
- W2287677104 cites W2017050785 @default.
- W2287677104 cites W2023056476 @default.
- W2287677104 cites W2030854533 @default.
- W2287677104 cites W2035241082 @default.
- W2287677104 cites W2036848594 @default.
- W2287677104 cites W2045269599 @default.
- W2287677104 cites W2054310403 @default.
- W2287677104 cites W2071936353 @default.
- W2287677104 cites W2078485482 @default.
- W2287677104 cites W2082103906 @default.
- W2287677104 cites W2086277161 @default.
- W2287677104 cites W2088670929 @default.
- W2287677104 cites W2092026554 @default.
- W2287677104 cites W2096774963 @default.
- W2287677104 cites W2101197781 @default.
- W2287677104 cites W2117322782 @default.
- W2287677104 cites W2127530271 @default.
- W2287677104 cites W2127650961 @default.
- W2287677104 cites W2135742252 @default.
- W2287677104 cites W2144823539 @default.
- W2287677104 cites W2152363904 @default.
- W2287677104 cites W2153836963 @default.
- W2287677104 cites W2158129922 @default.
- W2287677104 cites W2167481167 @default.
- W2287677104 doi "https://doi.org/10.3779/j.issn.1009-3419.2016.02.06" @default.
- W2287677104 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6015138" @default.
- W2287677104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26903163" @default.
- W2287677104 hasPublicationYear "2016" @default.
- W2287677104 type Work @default.
- W2287677104 sameAs 2287677104 @default.
- W2287677104 citedByCount "0" @default.
- W2287677104 crossrefType "journal-article" @default.
- W2287677104 hasAuthorship W2287677104A5039226759 @default.
- W2287677104 hasAuthorship W2287677104A5056994271 @default.
- W2287677104 hasConcept C104317684 @default.
- W2287677104 hasConcept C150194340 @default.
- W2287677104 hasConcept C190727270 @default.
- W2287677104 hasConcept C24284526 @default.
- W2287677104 hasConcept C33288867 @default.
- W2287677104 hasConcept C502942594 @default.
- W2287677104 hasConcept C54355233 @default.
- W2287677104 hasConcept C552990157 @default.
- W2287677104 hasConcept C64927066 @default.
- W2287677104 hasConcept C83640560 @default.
- W2287677104 hasConcept C86339819 @default.
- W2287677104 hasConcept C86803240 @default.
- W2287677104 hasConcept C95444343 @default.
- W2287677104 hasConceptScore W2287677104C104317684 @default.
- W2287677104 hasConceptScore W2287677104C150194340 @default.
- W2287677104 hasConceptScore W2287677104C190727270 @default.
- W2287677104 hasConceptScore W2287677104C24284526 @default.
- W2287677104 hasConceptScore W2287677104C33288867 @default.
- W2287677104 hasConceptScore W2287677104C502942594 @default.
- W2287677104 hasConceptScore W2287677104C54355233 @default.
- W2287677104 hasConceptScore W2287677104C552990157 @default.
- W2287677104 hasConceptScore W2287677104C64927066 @default.
- W2287677104 hasConceptScore W2287677104C83640560 @default.
- W2287677104 hasConceptScore W2287677104C86339819 @default.
- W2287677104 hasConceptScore W2287677104C86803240 @default.
- W2287677104 hasConceptScore W2287677104C95444343 @default.
- W2287677104 hasIssue "2" @default.
- W2287677104 hasLocation W22876771041 @default.
- W2287677104 hasLocation W22876771042 @default.
- W2287677104 hasOpenAccess W2287677104 @default.
- W2287677104 hasPrimaryLocation W22876771041 @default.
- W2287677104 hasRelatedWork W1971223895 @default.
- W2287677104 hasRelatedWork W1997914669 @default.
- W2287677104 hasRelatedWork W2016891566 @default.
- W2287677104 hasRelatedWork W2019572309 @default.
- W2287677104 hasRelatedWork W2032321494 @default.
- W2287677104 hasRelatedWork W2039193920 @default.
- W2287677104 hasRelatedWork W2075924981 @default.
- W2287677104 hasRelatedWork W2116531489 @default.
- W2287677104 hasRelatedWork W2129029894 @default.
- W2287677104 hasRelatedWork W2278105877 @default.
- W2287677104 hasVolume "19" @default.
- W2287677104 isParatext "false" @default.
- W2287677104 isRetracted "false" @default.
- W2287677104 magId "2287677104" @default.
- W2287677104 workType "article" @default.