FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2287683639> ?p ?o ?g. }

• W2287683639 endingPage "151" @default.
• W2287683639 startingPage "143" @default.
• W2287683639 abstract "Serum albumin (SA) is the main transporter of drugs in mammalian blood plasma. Here, we report the first crystal structure of equine serum albumin (ESA) in complex with antihistamine drug cetirizine at a resolution of 2.1Å. Cetirizine is bound in two sites--a novel drug binding site (CBS1) and the fatty acid binding site 6 (CBS2). Both sites differ from those that have been proposed in multiple reports based on equilibrium dialysis and fluorescence studies for mammalian albumins as cetirizine binding sites. We show that the residues forming the binding pockets in ESA are highly conserved in human serum albumin (HSA), and suggest that binding of cetirizine to HSA will be similar. In support of that hypothesis, we show that the dissociation constants for cetirizine binding to CBS2 in ESA and HSA are identical using tryptophan fluorescence quenching. Presence of lysine and arginine residues that have been previously reported to undergo nonenzymatic glycosylation in CBS1 and CBS2 suggests that cetirizine transport in patients with diabetes could be altered. A review of all available SA structures from the PDB shows that in addition to the novel drug binding site we present here (CBS1), there are two pockets on SA capable of binding drugs that do not overlap with fatty acid binding sites and have not been discussed in published reviews." @default.
• W2287683639 created "2016-06-24" @default.
• W2287683639 creator A5002200873 @default.
• W2287683639 creator A5006511805 @default.
• W2287683639 creator A5036245721 @default.
• W2287683639 creator A5051220504 @default.
• W2287683639 creator A5051843143 @default.
• W2287683639 date "2016-03-01" @default.
• W2287683639 modified "2023-10-16" @default.
• W2287683639 title "Crystal structure of equine serum albumin in complex with cetirizine reveals a novel drug binding site" @default.
• W2287683639 cites W1539796472 @default.
• W2287683639 cites W1980078657 @default.
• W2287683639 cites W1981271830 @default.
• W2287683639 cites W2016401253 @default.
• W2287683639 cites W2017578953 @default.
• W2287683639 cites W2026582002 @default.
• W2287683639 cites W2028689547 @default.
• W2287683639 cites W2029191775 @default.
• W2287683639 cites W2030517878 @default.
• W2287683639 cites W2036187452 @default.
• W2287683639 cites W2043447398 @default.
• W2287683639 cites W2058573317 @default.
• W2287683639 cites W2060296932 @default.
• W2287683639 cites W2063559020 @default.
• W2287683639 cites W2067921100 @default.
• W2287683639 cites W2070491483 @default.
• W2287683639 cites W2071550682 @default.
• W2287683639 cites W2079993358 @default.
• W2287683639 cites W2095619299 @default.
• W2287683639 cites W2097493124 @default.
• W2287683639 cites W2102694309 @default.
• W2287683639 cites W2103503400 @default.
• W2287683639 cites W2108921801 @default.
• W2287683639 cites W2124464974 @default.
• W2287683639 cites W2139163648 @default.
• W2287683639 cites W2144081223 @default.
• W2287683639 cites W2152604288 @default.
• W2287683639 cites W2153954921 @default.
• W2287683639 cites W2154714625 @default.
• W2287683639 cites W2159211495 @default.
• W2287683639 cites W2160378127 @default.
• W2287683639 cites W2163706749 @default.
• W2287683639 cites W2165419593 @default.
• W2287683639 cites W2235700303 @default.
• W2287683639 cites W2324955203 @default.
• W2287683639 cites W613390919 @default.
• W2287683639 doi "https://doi.org/10.1016/j.molimm.2016.02.003" @default.
• W2287683639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4800003" @default.
• W2287683639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26896718" @default.
• W2287683639 hasPublicationYear "2016" @default.
• W2287683639 type Work @default.
• W2287683639 sameAs 2287683639 @default.
• W2287683639 citedByCount "20" @default.
• W2287683639 countsByYear W22876836392016 @default.
• W2287683639 countsByYear W22876836392018 @default.
• W2287683639 countsByYear W22876836392019 @default.
• W2287683639 countsByYear W22876836392020 @default.
• W2287683639 countsByYear W22876836392021 @default.
• W2287683639 countsByYear W22876836392022 @default.
• W2287683639 countsByYear W22876836392023 @default.
• W2287683639 crossrefType "journal-article" @default.
• W2287683639 hasAuthorship W2287683639A5002200873 @default.
• W2287683639 hasAuthorship W2287683639A5006511805 @default.
• W2287683639 hasAuthorship W2287683639A5036245721 @default.
• W2287683639 hasAuthorship W2287683639A5051220504 @default.
• W2287683639 hasAuthorship W2287683639A5051843143 @default.
• W2287683639 hasBestOaLocation W22876836391 @default.
• W2287683639 hasConcept C107824862 @default.
• W2287683639 hasConcept C165616093 @default.
• W2287683639 hasConcept C170493617 @default.
• W2287683639 hasConcept C185592680 @default.
• W2287683639 hasConcept C2776125364 @default.
• W2287683639 hasConcept C2776706248 @default.
• W2287683639 hasConcept C2778597219 @default.
• W2287683639 hasConcept C2779463773 @default.
• W2287683639 hasConcept C2780035454 @default.
• W2287683639 hasConcept C515207424 @default.
• W2287683639 hasConcept C51639874 @default.
• W2287683639 hasConcept C55493867 @default.
• W2287683639 hasConcept C74998103 @default.
• W2287683639 hasConcept C86803240 @default.
• W2287683639 hasConcept C98274493 @default.
• W2287683639 hasConceptScore W2287683639C107824862 @default.
• W2287683639 hasConceptScore W2287683639C165616093 @default.
• W2287683639 hasConceptScore W2287683639C170493617 @default.
• W2287683639 hasConceptScore W2287683639C185592680 @default.
• W2287683639 hasConceptScore W2287683639C2776125364 @default.
• W2287683639 hasConceptScore W2287683639C2776706248 @default.
• W2287683639 hasConceptScore W2287683639C2778597219 @default.
• W2287683639 hasConceptScore W2287683639C2779463773 @default.
• W2287683639 hasConceptScore W2287683639C2780035454 @default.
• W2287683639 hasConceptScore W2287683639C515207424 @default.
• W2287683639 hasConceptScore W2287683639C51639874 @default.
• W2287683639 hasConceptScore W2287683639C55493867 @default.
• W2287683639 hasConceptScore W2287683639C74998103 @default.
• W2287683639 hasConceptScore W2287683639C86803240 @default.
• W2287683639 hasConceptScore W2287683639C98274493 @default.
• W2287683639 hasFunder F4320308158 @default.

• next