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- W2287750079 abstract "BACKGROUND Epithelial ovarian cancer (EOC) is the most lethal malignant gynecological cancer. MicroRNAs (miRNAs) play important roles in the pathogenesis of ovarian cancer. The role of miR-494 in EOC has not been fully investigated. MATERIAL AND METHODS MiR-494 levels in ovarian cancer tissues and cells were tested by qRT-PCR. Cells were transfected with miR-494 mimics or miR-494 ASO by Lipofectamine. Bioinformatics algorithms from TargetScanHuman were used to predict the target genes of miR-494. The c-Myc protein level was assayed by Western blot. The interaction between miR-494 and c-Myc was confirmed by dual luciferase assays. RESULTS MiR-494 showed low levels in EOC tissues and cells. Overexpression of miR-494 inhibited cell growth and migration of EOC cells and vice versa. c-Myc is the targeted gene of miR-494. CONCLUSIONS MiR-494 has an anti-tumor role in EOC via c-Myc." @default.
- W2287750079 created "2016-06-24" @default.
- W2287750079 creator A5006517133 @default.
- W2287750079 creator A5027161263 @default.
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- W2287750079 date "2016-02-24" @default.
- W2287750079 modified "2023-10-18" @default.
- W2287750079 title "MiR-494 Inhibits Epithelial Ovarian Cancer Growth by Targeting c-Myc" @default.
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- W2287750079 doi "https://doi.org/10.12659/msm.897288" @default.
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