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- W2287750419 abstract "The African trypanosomes T. equiperdum and T. evansi are two pathogenic species in horses with a wide distribution in countries in tropical and subtropical areas of Africa, Asia and part of Europe in the first case and in Africa, Asia and America for the second. These species are the etiological agents of Dourine and Surra or Derrengadera respectively; both are morphologically and antigenically related. It is only possible to differentiate both species by the clinical symptoms and the mechanism of transmission of the infection, which is through coitus for T. equiperdum and by insect bites by hematophagous flies for T. evansi. Secreting hybrids of monoclonal antibodies were prepared against T. equiperdum and T. evansi. They were used a total hydrolyzed antigens for both species and injected in female Balb/c mice intraperitoneally without adjuvant. The hybridomas were cloned and subcloned and seven positive hybridomas were obtained for each trypanosome species. The monoclonal antibodies for both species proved to have relatively low titles (1:80); to be of the IgM class and to have a high cross reactivity with antigens of both species. They were unable to react against separated antigens in western blotting. They reacted appropriately against antigens in ELISA. Our results demonstrate that both species are antigenically very similar, probably due to the structure of the glycosidic moiety of the VSG. These monoclonal antibodies can be useful as tools for the identification and detection of these Trypanosoma species where they do not occur in mixed infections (East Europe and America)." @default.
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- W2287750419 date "2002-01-01" @default.
- W2287750419 modified "2023-09-28" @default.
- W2287750419 title "Anticuerpos monoclonales producidos ontra trypanosoma equiperdum y trypanosoma evansi reconocen ambas especies" @default.
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