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- W2287863353 abstract "Objective: To study the effect of 2,3,5,4-tetrahydroxystilbene-2-O-β-D glucoside (THSG) on the proliferation of human breast cancer MCF-7 cells and phosphoinositol-3-kinase/Akt (PI3K/Akt) signaling pathway. Methods: The proliferation of MCF-7 cells was measured with MTT assay and the apoptotic rate of MCF-7 cells was determined by flow cytometry. The levels of PTEN, phosphorylated PKB (p-PKB), cyclin D1, Bcl-2, caspase-3 and NF-κB protein expression were examined by Western blotting. The expression level of PTEN mRNA was detected by semi-quantitative RT-PCR. Results: THSG 1, 10, and 100 μmol/L obviously inhibited MCF-7 cell proliferation after 24-, 48-, and 72-h treatment. THSG 100 μmol/L decreased the proliferation of MCF-7 cells by 41.8% at 48 h (P＜0.05). But THSG at a low concentration (0.1 and 0.01 μmol/L) had weak effects in inducing the proliferation of MCF-7 cells. After treatment with 1, 10, and 100 μmol/L of THSG for 48 h,the apoptotic rate of MCF-7 cells was (6.25±0.65)%, (5.04±0.83)%, and (7.98±0.67)%, respectively. THSG 1, 10, and 100 μmol/L upregulated the level of PTEN protein and downregulated the expressions of p-PKB and cyclin D1 in a dose-dependent manner. THSG had no significant effects on the expression of Bcl-2, caspase-3,and NF-κB. THSG induced weak upregulation of PTEN mRNA expression. Conclusion: THSG inhibited the proliferation of MCF-7 cells. The effects may be achieved through depressing PI3K/Akt signaling pathway." @default.
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- W2287863353 date "2009-01-25" @default.
- W2287863353 modified "2023-09-27" @default.
- W2287863353 title "二苯乙烯苷抑制人乳腺癌MCF-7细胞增殖及对PI3K/Akt信号通路的影响" @default.
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