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• W2287910583 abstract "Objective To explore the effort of Bailing capsule on epithelial-mesenchymal transition (EMT) in rats with adenine-induced tubulointerstitial fibrosis. Methods Tubulointerstitial fibrosis animal models were established and SD rats were divided into model group (n=30), treatment group (n=30) and control group (n=30), randomly. Experimental rats were harvested at 7 w, 12 w, 17 w after onset of experiment and functional evaluations were performed. Histology, immunohistology were examined to investigate both histolopathology changes and the expression of bone morphogenic protein-7 (BMP-7), transforming growth factor-β1 (TGF-β1) and a-smooth muscle actin (α-SMA) in kidneys at three time points mentioned above, respectively. Results Compared with control group, 24 h urinary protein in model group lost increasingly and significantly difference appeared at three time points relative to control group(P＜0.01). Urinary NAG in model group was markedly higher than that in control group from 7 w after onset (P＜0.01) mad was increasingly raised at 12 w and 17 w (P＜0.01). The value of blood BUN and Cr in model group increased at 7 w (P＞0.05) relative to control group. There was significant difference at 12 w and 17 w (P＜0.01). Histologically, kidneys in model group, at 7 w. exhibited tubular casts and gently tubular dilation, granuloma in cortex, mononuclear cells infiltration in tubulointerstitial areas, and mild interstitial fibrosis. At 12 w, the degree of tubular injury and tubulointerstitial fibrosis gradually aggravated. Up to 17 w, diffuse tubular dilation or atrophy was observed and focal tubules disappear. Diffuse interstitial fibrosis was exhibited. In normal kidneys, immunohistochemistry suggested that the light expression of BMP-7 was detected in proximal renal tubular epithelial cells and marked expression was identified in distal tubule, collecting duct, and renal tubular epithelial in junction area between cortex and medulla, However, the expression of BMP-7 in kidneys of model group significantly decreased with increasing tubulointerstitial fibrosis and was negative correlation with the expression of TGF-β1 (r=-0.981 P＜0.01) and α-SMA (r=-0.975 P＜0.01). Bailing capsule administration protected the expression of BMP-7 and reduced TGF-β1 and α-SMA expression before 12 w(P＜0.01). Conclusions Our study shows an anti-fibrotic reno-protective function of Bailing capsule in rats with tubulointerstitial fibrosis via prevention of epithelial-mesenchymal transition at early stage. However, the beneficial effect lost with increasing tabulointerstitial fibrosis." @default.
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• W2287910583 date "2005-09-20" @default.
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• W2287910583 title "Bailing Capsule in Preventing Epithelial-Mesenchymal Transition in Rats with Tubulointerstitial Fibrosis" @default.
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