Matches in SemOpenAlex for { <https://semopenalex.org/work/W2287996810> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2287996810 endingPage "R412" @default.
- W2287996810 startingPage "R404" @default.
- W2287996810 abstract "We have exposed primary dispersed hypothalamic cultures from 14-day-old fetal Sprague-Dawley rats to substances known to either elevate adenosine 3',5'-cyclic monophosphate (cAMP) levels or increase vasopressin (VP) secretion. The levels of VP in the medium collected from the cultures were determined by radioimmunoassay, and the number of neurophysin (NP)-positive cells after immunohistochemistry was counted. cAMP-elevating agents, 3-isobutyl-1-methylxanthine (200 microM) and forskolin (25 microM), in combination (I-F) maintained NP synthesis and VP secretion in 19-day cultures. I-F replacement by K+ (28 mM), isoproterenol (10 microM), glutamate (10 microM), or bicuculline (10 microM) during the last week of culture resulted in maintenance of NP expression and transient stimulation of VP secretion, but these agents did not induce NP expression independently of I-F treatment. In contrast, exposure to the dopamine D1 agonist SKF-38393 (10 microM) significantly increased NP expression independently and after replacement of I-F. Dopamine D1A receptors were detected by immunofluorescence on NP-expressing cells, providing a morphological basis for this response. These results suggest a role for D1A receptors in the regulation of VP gene expression." @default.
- W2287996810 created "2016-06-24" @default.
- W2287996810 creator A5011202431 @default.
- W2287996810 creator A5063073775 @default.
- W2287996810 creator A5082046729 @default.
- W2287996810 creator A5088164724 @default.
- W2287996810 date "1996-02-01" @default.
- W2287996810 modified "2023-09-23" @default.
- W2287996810 title "Neurophysin expression is stimulated by dopamine D1 agonist in dispersed hypothalamic cultures" @default.
- W2287996810 doi "https://doi.org/10.1152/ajpregu.1996.270.2.r404" @default.
- W2287996810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8779872" @default.
- W2287996810 hasPublicationYear "1996" @default.
- W2287996810 type Work @default.
- W2287996810 sameAs 2287996810 @default.
- W2287996810 citedByCount "4" @default.
- W2287996810 crossrefType "journal-article" @default.
- W2287996810 hasAuthorship W2287996810A5011202431 @default.
- W2287996810 hasAuthorship W2287996810A5063073775 @default.
- W2287996810 hasAuthorship W2287996810A5082046729 @default.
- W2287996810 hasAuthorship W2287996810A5088164724 @default.
- W2287996810 hasConcept C126322002 @default.
- W2287996810 hasConcept C134018914 @default.
- W2287996810 hasConcept C170493617 @default.
- W2287996810 hasConcept C185592680 @default.
- W2287996810 hasConcept C24998067 @default.
- W2287996810 hasConcept C2776219046 @default.
- W2287996810 hasConcept C2776668983 @default.
- W2287996810 hasConcept C2776991684 @default.
- W2287996810 hasConcept C2778938600 @default.
- W2287996810 hasConcept C2779276759 @default.
- W2287996810 hasConcept C513476851 @default.
- W2287996810 hasConcept C71924100 @default.
- W2287996810 hasConcept C86803240 @default.
- W2287996810 hasConceptScore W2287996810C126322002 @default.
- W2287996810 hasConceptScore W2287996810C134018914 @default.
- W2287996810 hasConceptScore W2287996810C170493617 @default.
- W2287996810 hasConceptScore W2287996810C185592680 @default.
- W2287996810 hasConceptScore W2287996810C24998067 @default.
- W2287996810 hasConceptScore W2287996810C2776219046 @default.
- W2287996810 hasConceptScore W2287996810C2776668983 @default.
- W2287996810 hasConceptScore W2287996810C2776991684 @default.
- W2287996810 hasConceptScore W2287996810C2778938600 @default.
- W2287996810 hasConceptScore W2287996810C2779276759 @default.
- W2287996810 hasConceptScore W2287996810C513476851 @default.
- W2287996810 hasConceptScore W2287996810C71924100 @default.
- W2287996810 hasConceptScore W2287996810C86803240 @default.
- W2287996810 hasIssue "2" @default.
- W2287996810 hasLocation W22879968101 @default.
- W2287996810 hasLocation W22879968102 @default.
- W2287996810 hasOpenAccess W2287996810 @default.
- W2287996810 hasPrimaryLocation W22879968101 @default.
- W2287996810 hasRelatedWork W100928883 @default.
- W2287996810 hasRelatedWork W1990387475 @default.
- W2287996810 hasRelatedWork W2017770252 @default.
- W2287996810 hasRelatedWork W2051696360 @default.
- W2287996810 hasRelatedWork W2052467419 @default.
- W2287996810 hasRelatedWork W2058991568 @default.
- W2287996810 hasRelatedWork W2073752531 @default.
- W2287996810 hasRelatedWork W2074641809 @default.
- W2287996810 hasRelatedWork W2111485979 @default.
- W2287996810 hasRelatedWork W4236170379 @default.
- W2287996810 hasVolume "270" @default.
- W2287996810 isParatext "false" @default.
- W2287996810 isRetracted "false" @default.
- W2287996810 magId "2287996810" @default.
- W2287996810 workType "article" @default.