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• W2288023718 abstract "In 1875, Paul Bert linked high altitude danger to the low partial pressure of oxygen when 2 of 3 French balloonists died euphorically at about 8,600 m altitude. World War I fatal crashes of high altitude fighter pilots led to a century of efforts to use oximetry to warn pilots. The carotid body, discovered in 1932 to be the hypoxia detector, led to most current physiologic understanding of the body's respiratory responses to hypoxia and CO 2 . The author describes some of his UCSF group's work: In 1963, we reported both the brain's ventral medullary near-surface CO 2 (and pH) chemosensors and the role of cerebrospinal fluid in acclimatization to altitude. In 1966, we reported the effect of altitude on cerebral blood flow and later the changes of carotid body sensitivity at altitude and the differences in natives of high altitude. In 1973, pulse oximetry was invented when Japanese biophysicist Takuo Aoyagi read and applied to pulses a largely forgotten 35-year-old discovery by English medical student J. R. Squire of a method of computing oxygen saturation from red and infrared light passing through both perfused and blanched tissue." @default.
• W2288023718 created "2016-06-24" @default.
• W2288023718 creator A5087705095 @default.
• W2288023718 date "2016-01-15" @default.
• W2288023718 modified "2023-09-24" @default.
• W2288023718 title "HIGH LIFE: High altitude fatalities led to pulse oximetry" @default.
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• W2288023718 doi "https://doi.org/10.1152/japplphysiol.00476.2015" @default.
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