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- W2288082103 abstract "Objective Assess adaptations of hepatic lipid metabolism in response to high-fat diet (HFD). Methods Male Wistar rats (14 wk) were fed either normal chow (NC, 9 En% fat) or HFD (45.7 En% fat) ad libitum for 2.5 wk and 25 wk (n=10 per diet group). Intrahepatic lipids (IHL) were assessed using in vivo 1H magnetic resonance spectroscopy and Oil Red O staining. Fatty acids (FA) were quantified using gas chromatography. Mitochondrial function and DNA (mtDNA) copy number was assessed using high-resolution respirometry and quantitative PCR, respectively. Results HFD feeding resulted in obese and glucose intolerant phenotype. Oil Red O staining showed that HFD feeding induced microvesicular steatosis. The content of IHL and FA increased with increasing duration of HFD feeding. The strongest effect was observed on the content of mono-unsaturated FA (predominantly oleate), which may be due to increased activity of stearoyl-CoA desaturase. HFD feeding stimulated mitochondrial biogenesis and oxidative FA metabolism as indicated by increase in mtDNA copy number and higher palmitoyl-L-carnitine-driven oxygen consumption rate in state 3. Conclusions HFD feeding leads to accumulation of hepatic TAG despite of increased capacity to oxidize FA, indicating that the latter adaptations are insufficient to cope with oversupply of dietary lipids. This work was financed by the Netherlands Consortium for Systems Biology." @default.
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- W2288082103 date "2010-04-01" @default.
- W2288082103 modified "2023-10-16" @default.
- W2288082103 title "Increased capacity to oxidize fatty acids does not prevent development of hepatic steatosis in high‐fat diet fed rats" @default.
- W2288082103 doi "https://doi.org/10.1096/fasebj.24.1_supplement.597.1" @default.
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