FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2288204533> ?p ?o ?g. }

• W2288204533 startingPage "37" @default.
• W2288204533 abstract "Mr. R, age 75, is having difficulty sleeping. When he goes to bed, he lies there for what seems like forever, unable to fall asleep. He feels so tired and ends up taking naps during the day, but he cannot break this cycle. He has tried using over-the-counter products with little relief. Mr. R's primary care physician prescribes zaleplon, 10 mg/d, and asks him to call the clinic in 2 weeks to discuss his progress. He takes zaleplon as directed for several nights and begins to feel sluggish during the day, both mentally and physically, despite reporting an increase in the overall amount of sleep at night. Sedative-hypnotic drugs are among the most commonly used medications in the United States. Use of these drugs, as well as anxiolytics, has increased from 2.8% between 1988 and 1994 to 4.7% between 2007 and 2010, according to the Department of Health and Human Services. (1) In 2011, drugs categorized as sedative-hypnotics or antipsychotics were involved in 6.1% of all human exposures identified in the American Association of Poison Control Centers' National Poison Data System. (2) Therefore, an understanding of clinical and pharmacological variables related to safe and effective use is important for clinicians prescribing and monitoring therapy with these agents. Neuropsychiatric disorders are prevalent among geriatric patients and are associated with age-related physiologic changes in the CNS. (3) Such changes involve: * neuroanatomy (brain atrophy, decreased neuronal density, increased plaque formation) * neurotransmitters (reduced cholinergic transmission, decreased synthesis of dopamine and catecholamines), and * neurophysiology (reduced cerebral blood flow). These physiologic processes manifest as alterations in mental status, reflexes, sensation, gait, balance, and sleep. Examples of sleep changes among geriatric patients include decreased sleep efficiency, more frequent awakenings, and more variable sleep duration. (3), (4) Sleep disorders also may be related to mental disorders and other medical conditions. (5) For example, the prevalence of sleep-related respiratory disorders, such as obstructive sleep apnea and central sleep apnea, increases with age. (6) Sleep disorders are common among geriatric patients. In a large epidemiologic study of sleep complaints in patients age [greater than or equal to]65, more than one-half of patients had at least 1 sleep complaint (ie, difficulty falling asleep, trouble waking up, early awakening, need for naps, and feeling ill-rested). (7) As many as 34% of patients reported symptoms of insomnia. In an analysis of National Ambulatory Medical Survey Data over 6 years, 24.8% to 27.9% of sleep-related medical office visits were attributed to patients age [greater than or equal to]65. (8) Pharmacology in aging Prescribing sedative-hypnotic drugs is not routinely recommended for older patients with a sleep disorder. Geriatric patients, compared with younger patients, are at higher risk of iatrogenic complications because of polypharmacy, comorbidities, relative renal and hepatic insufficiency, and other physiologic changes leading to alterations in drug exposure and metabolism (Table 1).(9-12) Aging is associated with changes in body composition, including an increase in total body fat and decrease in lean body mass and total body water. These changes, as well as a prolonged GI transit time, decrease in active gut transporters, decreased blood perfusion, and decrease in plasma proteins such as albumin (because of 'educed liver function or malnutrition), may lead to alteration in drug absorption patterns and may increase the volume of distribution for lipophilic drugs. Additionally, the elimination half-life of some drugs may increase with age because of larger volumes of distribution and reduction in hepatic or renal clearance. The clinical significance of these changes is not well established. …" @default.
• W2288204533 created "2016-06-24" @default.
• W2288204533 creator A5033047276 @default.
• W2288204533 creator A5035302466 @default.
• W2288204533 date "2014-10-01" @default.
• W2288204533 modified "2023-09-26" @default.
• W2288204533 title "Geriatric Patients: Choose Wisely: Age-Related Physiologic Changes, Risk of Adverse Effects Guide Your Prescribing" @default.
• W2288204533 hasPublicationYear "2014" @default.
• W2288204533 type Work @default.
• W2288204533 sameAs 2288204533 @default.
• W2288204533 citedByCount "0" @default.
• W2288204533 crossrefType "journal-article" @default.
• W2288204533 hasAuthorship W2288204533A5033047276 @default.
• W2288204533 hasAuthorship W2288204533A5035302466 @default.
• W2288204533 hasConcept C118552586 @default.
• W2288204533 hasConcept C197934379 @default.
• W2288204533 hasConcept C2777602617 @default.
• W2288204533 hasConcept C2910067630 @default.
• W2288204533 hasConcept C63433958 @default.
• W2288204533 hasConcept C71924100 @default.
• W2288204533 hasConcept C98274493 @default.
• W2288204533 hasConceptScore W2288204533C118552586 @default.
• W2288204533 hasConceptScore W2288204533C197934379 @default.
• W2288204533 hasConceptScore W2288204533C2777602617 @default.
• W2288204533 hasConceptScore W2288204533C2910067630 @default.
• W2288204533 hasConceptScore W2288204533C63433958 @default.
• W2288204533 hasConceptScore W2288204533C71924100 @default.
• W2288204533 hasConceptScore W2288204533C98274493 @default.
• W2288204533 hasIssue "10" @default.
• W2288204533 hasLocation W22882045331 @default.
• W2288204533 hasOpenAccess W2288204533 @default.
• W2288204533 hasPrimaryLocation W22882045331 @default.
• W2288204533 hasRelatedWork W1506499152 @default.
• W2288204533 hasRelatedWork W1869082655 @default.
• W2288204533 hasRelatedWork W2010628202 @default.
• W2288204533 hasRelatedWork W2014849499 @default.
• W2288204533 hasRelatedWork W2054242172 @default.
• W2288204533 hasRelatedWork W2153260846 @default.
• W2288204533 hasRelatedWork W2172933601 @default.
• W2288204533 hasRelatedWork W2231641334 @default.
• W2288204533 hasRelatedWork W235359427 @default.
• W2288204533 hasRelatedWork W2394667023 @default.
• W2288204533 hasRelatedWork W2406144159 @default.
• W2288204533 hasRelatedWork W2416654440 @default.
• W2288204533 hasRelatedWork W263051782 @default.
• W2288204533 hasRelatedWork W2807387441 @default.
• W2288204533 hasRelatedWork W2910470062 @default.
• W2288204533 hasRelatedWork W2926368843 @default.
• W2288204533 hasRelatedWork W3045261500 @default.
• W2288204533 hasRelatedWork W3095896131 @default.
• W2288204533 hasRelatedWork W381364672 @default.
• W2288204533 hasRelatedWork W2224489053 @default.
• W2288204533 hasVolume "13" @default.
• W2288204533 isParatext "false" @default.
• W2288204533 isRetracted "false" @default.
• W2288204533 magId "2288204533" @default.
• W2288204533 workType "article" @default.