Matches in SemOpenAlex for { <https://semopenalex.org/work/W2288312466> ?p ?o ?g. }
- W2288312466 abstract "Abstract Two novel approaches were recently suggested for genome-wide identification of protein aspects synthesized at a given time. Ribo-Seq is based on sequencing all the ribosome protected mRNA fragments in a cell, while PUNCH-P is based on mass-spectrometric analysis of only newly synthesized proteins. Here we describe the first Ribo-Seq/PUNCH-P comparison via the analysis of mammalian cells during the cell-cycle for detecting relevant differentially expressed genes between G1 and M phase. Our analyses suggest that the two approaches significantly overlap with each other. However, we demonstrate that there are biologically meaningful proteins/genes that can be detected to be post-transcriptionally regulated during the mammalian cell cycle only by each of the approaches, or their consolidation. Such gene sets are enriched with proteins known to be related to intra-cellular signalling pathways such as central cell cycle processes, central gene expression regulation processes, processes related to chromosome segregation, DNA damage and replication, that are post-transcriptionally regulated during the mammalian cell cycle. Moreover, we show that combining the approaches better predicts steady state changes in protein abundance. The results reported here support the conjecture that for gaining a full post-transcriptional regulation picture one should integrate the two approaches." @default.
- W2288312466 created "2016-06-24" @default.
- W2288312466 creator A5001754712 @default.
- W2288312466 creator A5021278923 @default.
- W2288312466 creator A5080818955 @default.
- W2288312466 date "2016-02-22" @default.
- W2288312466 modified "2023-10-06" @default.
- W2288312466 title "Complementary Post Transcriptional Regulatory Information is Detected by PUNCH-P and Ribosome Profiling" @default.
- W2288312466 cites W1953939973 @default.
- W2288312466 cites W1963396472 @default.
- W2288312466 cites W1964330084 @default.
- W2288312466 cites W1973268693 @default.
- W2288312466 cites W1973364414 @default.
- W2288312466 cites W1981215030 @default.
- W2288312466 cites W1981601285 @default.
- W2288312466 cites W1993009001 @default.
- W2288312466 cites W1994803330 @default.
- W2288312466 cites W2003516452 @default.
- W2288312466 cites W2008510122 @default.
- W2288312466 cites W2009512566 @default.
- W2288312466 cites W2009537684 @default.
- W2288312466 cites W2013947447 @default.
- W2288312466 cites W2017728350 @default.
- W2288312466 cites W2019196704 @default.
- W2288312466 cites W2024083852 @default.
- W2288312466 cites W2025569664 @default.
- W2288312466 cites W2026570758 @default.
- W2288312466 cites W2028133290 @default.
- W2288312466 cites W2028386037 @default.
- W2288312466 cites W2028931227 @default.
- W2288312466 cites W2036321220 @default.
- W2288312466 cites W2036897871 @default.
- W2288312466 cites W2038598202 @default.
- W2288312466 cites W2040676413 @default.
- W2288312466 cites W2042215748 @default.
- W2288312466 cites W2043458577 @default.
- W2288312466 cites W2044692345 @default.
- W2288312466 cites W2047291244 @default.
- W2288312466 cites W2051242197 @default.
- W2288312466 cites W2053460598 @default.
- W2288312466 cites W2053835153 @default.
- W2288312466 cites W2054269398 @default.
- W2288312466 cites W2055639102 @default.
- W2288312466 cites W2057549495 @default.
- W2288312466 cites W2058852389 @default.
- W2288312466 cites W2061912939 @default.
- W2288312466 cites W2071030970 @default.
- W2288312466 cites W2071849521 @default.
- W2288312466 cites W2076034830 @default.
- W2288312466 cites W2079517684 @default.
- W2288312466 cites W2080752012 @default.
- W2288312466 cites W2086157203 @default.
- W2288312466 cites W2086227169 @default.
- W2288312466 cites W2086758397 @default.
- W2288312466 cites W2093509030 @default.
- W2288312466 cites W2099131261 @default.
- W2288312466 cites W2101181377 @default.
- W2288312466 cites W2102281458 @default.
- W2288312466 cites W2108238425 @default.
- W2288312466 cites W2108468293 @default.
- W2288312466 cites W2115662277 @default.
- W2288312466 cites W2117327695 @default.
- W2288312466 cites W2119142553 @default.
- W2288312466 cites W2122438081 @default.
- W2288312466 cites W2122863289 @default.
- W2288312466 cites W2123724865 @default.
- W2288312466 cites W2124985265 @default.
- W2288312466 cites W2127745643 @default.
- W2288312466 cites W2128551987 @default.
- W2288312466 cites W2129178024 @default.
- W2288312466 cites W2130687290 @default.
- W2288312466 cites W2133968430 @default.
- W2288312466 cites W2135030836 @default.
- W2288312466 cites W2135688535 @default.
- W2288312466 cites W2140486583 @default.
- W2288312466 cites W2141355300 @default.
- W2288312466 cites W2141458291 @default.
- W2288312466 cites W2141781797 @default.
- W2288312466 cites W2142482793 @default.
- W2288312466 cites W2144014661 @default.
- W2288312466 cites W2146308594 @default.
- W2288312466 cites W2147068611 @default.
- W2288312466 cites W2147438029 @default.
- W2288312466 cites W2147837708 @default.
- W2288312466 cites W2148342439 @default.
- W2288312466 cites W2150566147 @default.
- W2288312466 cites W2150782426 @default.
- W2288312466 cites W2151936673 @default.
- W2288312466 cites W2152239989 @default.
- W2288312466 cites W2154431984 @default.
- W2288312466 cites W2155804510 @default.
- W2288312466 cites W2157705406 @default.
- W2288312466 cites W2159317228 @default.
- W2288312466 cites W2159675211 @default.
- W2288312466 cites W2160215304 @default.
- W2288312466 cites W2161616648 @default.
- W2288312466 cites W2165253681 @default.
- W2288312466 cites W2166053360 @default.
- W2288312466 cites W2167540700 @default.
- W2288312466 cites W2169805130 @default.