FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2288331528> ?p ?o ?g. }

• W2288331528 endingPage "1003" @default.
• W2288331528 startingPage "990" @default.
• W2288331528 abstract "Meta-analyses of antidepressant drug treatment trials have found that increasing age is associated with a less favourable outcome. Because the prevalence of geriatric characteristics, like disability, medical co-morbidity, malnutrition, cognitive (dys)function and frailty increase with age and are associated with depression, these characteristics are likely to modify the treatment outcome of antidepressant drugs in late-life depression. This review examines how these five characteristics are taken into account in randomised controlled trials (RCTs) with antidepressant drugs for major depressive disorder in patients aged 60 years or above.A systematic search in PubMED, PsychInfo and EMBASE, from the year 2000 onwards, yielded 27 RCTs, with a total of 6356 subjects with a median age of 71 years. Two reviewers independently assessed whether each characteristic was considered as inclusion or exclusion criterion, descriptive variable, stratification variable, co-variable, outcome measure, or in adverse effect monitoring.Malnutrition and frailty were not taken into account in any study. Disability was used as an outcome measure in five studies. Two studies explicitly included a population with possibly serious medical co-morbidity. Cognitive status was the only condition taken into account as co-variable (n = 3) or stratifying variable (n = 1) and was used as outcome measure in seven studies.We conclude that geriatric characteristics are rarely taken into account in RCTs on antidepressant drugs in late-life depression, and studies including the oldest adults are underrepresented. This warrants recruitment of the oldest adults and adjustment of treatment strategies in future studies. Copyright © 2016 John Wiley & Sons, Ltd." @default.
• W2288331528 created "2016-06-24" @default.
• W2288331528 creator A5024730616 @default.
• W2288331528 creator A5029136789 @default.
• W2288331528 creator A5038192809 @default.
• W2288331528 creator A5053561312 @default.
• W2288331528 creator A5067172217 @default.
• W2288331528 creator A5078789772 @default.
• W2288331528 date "2016-02-28" @default.
• W2288331528 modified "2023-10-16" @default.
• W2288331528 title "Geriatric characteristics in randomised controlled trials on antidepressant drugs for older adults: a systematic review" @default.
• W2288331528 cites W1503668654 @default.
• W2288331528 cites W1524088676 @default.
• W2288331528 cites W168467554 @default.
• W2288331528 cites W1846868862 @default.
• W2288331528 cites W1931781407 @default.
• W2288331528 cites W1975916217 @default.
• W2288331528 cites W1975934950 @default.
• W2288331528 cites W1984979845 @default.
• W2288331528 cites W1987544980 @default.
• W2288331528 cites W1993810702 @default.
• W2288331528 cites W1994862345 @default.
• W2288331528 cites W1997085678 @default.
• W2288331528 cites W2003386818 @default.
• W2288331528 cites W2011606125 @default.
• W2288331528 cites W2021612723 @default.
• W2288331528 cites W2029593151 @default.
• W2288331528 cites W2029846038 @default.
• W2288331528 cites W2035130373 @default.
• W2288331528 cites W2035716594 @default.
• W2288331528 cites W2043842622 @default.
• W2288331528 cites W2044095917 @default.
• W2288331528 cites W2045543396 @default.
• W2288331528 cites W2045775503 @default.
• W2288331528 cites W2048340122 @default.
• W2288331528 cites W2048929476 @default.
• W2288331528 cites W2053023493 @default.
• W2288331528 cites W2054398897 @default.
• W2288331528 cites W2057239589 @default.
• W2288331528 cites W2060854717 @default.
• W2288331528 cites W2063757992 @default.
• W2288331528 cites W2071625252 @default.
• W2288331528 cites W2073185943 @default.
• W2288331528 cites W2075544268 @default.
• W2288331528 cites W2084158133 @default.
• W2288331528 cites W2084253648 @default.
• W2288331528 cites W2084528484 @default.
• W2288331528 cites W2085644156 @default.
• W2288331528 cites W2087216612 @default.
• W2288331528 cites W2090180691 @default.
• W2288331528 cites W2096098628 @default.
• W2288331528 cites W2098644261 @default.
• W2288331528 cites W2107257411 @default.
• W2288331528 cites W2114613490 @default.
• W2288331528 cites W2120032954 @default.
• W2288331528 cites W2123559386 @default.
• W2288331528 cites W2124640962 @default.
• W2288331528 cites W2125403199 @default.
• W2288331528 cites W2131524336 @default.
• W2288331528 cites W2131823335 @default.
• W2288331528 cites W2131924085 @default.
• W2288331528 cites W2137785805 @default.
• W2288331528 cites W2142514031 @default.
• W2288331528 cites W2143313296 @default.
• W2288331528 cites W2153327521 @default.
• W2288331528 cites W2154855876 @default.
• W2288331528 cites W2155189765 @default.
• W2288331528 cites W2155943959 @default.
• W2288331528 cites W2158176267 @default.
• W2288331528 cites W2158186000 @default.
• W2288331528 cites W2163709153 @default.
• W2288331528 cites W2167534443 @default.
• W2288331528 cites W2167872155 @default.
• W2288331528 cites W2170475155 @default.
• W2288331528 cites W2170633057 @default.
• W2288331528 cites W2171562414 @default.
• W2288331528 cites W4240994224 @default.
• W2288331528 cites W4250861056 @default.
• W2288331528 cites W4251343486 @default.
• W2288331528 cites W4292806894 @default.
• W2288331528 cites W4297888589 @default.
• W2288331528 cites W4297914005 @default.
• W2288331528 doi "https://doi.org/10.1002/gps.4443" @default.
• W2288331528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26924120" @default.
• W2288331528 hasPublicationYear "2016" @default.
• W2288331528 type Work @default.
• W2288331528 sameAs 2288331528 @default.
• W2288331528 citedByCount "24" @default.
• W2288331528 countsByYear W22883315282016 @default.
• W2288331528 countsByYear W22883315282017 @default.
• W2288331528 countsByYear W22883315282018 @default.
• W2288331528 countsByYear W22883315282019 @default.
• W2288331528 countsByYear W22883315282020 @default.
• W2288331528 countsByYear W22883315282021 @default.
• W2288331528 countsByYear W22883315282022 @default.
• W2288331528 countsByYear W22883315282023 @default.
• W2288331528 crossrefType "journal-article" @default.
• W2288331528 hasAuthorship W2288331528A5024730616 @default.

• next