Matches in SemOpenAlex for { <https://semopenalex.org/work/W2288362262> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2288362262 endingPage "1021" @default.
- W2288362262 startingPage "1017" @default.
- W2288362262 abstract "In the current study, the ex vivo permeation of ropinirole hydrochloride (RH) across porcine buccal mucosa in the presence of three permeation enhancers, namely N-trimethyl chitosan (TMC) (positively charged) a chitosan derivative, sulfobutyl ether-β-cyclodextrin (SBE-β-CD) (negatively charged) and hydroxypropyl-β-cyclodextrin (HP-β-CD) (neutral), was investigated. Buccal permeation studies were conducted using Franz diffusion cells. Cumulative amounts of RH were plotted versus time. The presence of the permeation enhancers significantly increased the transport of the drug across the porcine buccal epithelium compared to its plain congener (RH solution). The rank order effect of the permeation enhancers for the transport of RH across buccal epithelium was TMC ≥ SBE-β-CD > HP-β-CD > RH solution. The presence of TMC increased 1.34-fold the transport of RH across buccal epithelium, whereas an increase of 1.23- and 1.28-fold was reported in the presence of HP-β-CD and SBE-β-CD, respectively. Infrared spectroscopy (IR) was employed to investigate the interaction of permeation enhancers with the epithelial lipids of porcine buccal mucosa corroborating the permeation results. Finally, light microscopy was performed to assess the histological changes in the porcine epithelium. Formation of vacuoles, spongiosis and acantholysis linear detachment and destruction of the epithelium resulted from the presence of the permeation enhancers. The data suggest that all enhancers tested, and particularly TMC, increase the transport of RH across buccal epithelium." @default.
- W2288362262 created "2016-06-24" @default.
- W2288362262 creator A5013645115 @default.
- W2288362262 creator A5018860090 @default.
- W2288362262 creator A5034529578 @default.
- W2288362262 creator A5035166227 @default.
- W2288362262 creator A5055611807 @default.
- W2288362262 creator A5073357394 @default.
- W2288362262 creator A5091628026 @default.
- W2288362262 date "2016-01-21" @default.
- W2288362262 modified "2023-10-06" @default.
- W2288362262 title "<i>Ex vivo</i> buccal drug delivery of ropinirole hydrochloride in the presence of permeation enhancers: the effect of charge" @default.
- W2288362262 cites W1969207169 @default.
- W2288362262 cites W1969654223 @default.
- W2288362262 cites W1979484462 @default.
- W2288362262 cites W1985763351 @default.
- W2288362262 cites W1993345718 @default.
- W2288362262 cites W2005310862 @default.
- W2288362262 cites W2008336471 @default.
- W2288362262 cites W2026533497 @default.
- W2288362262 cites W2037346345 @default.
- W2288362262 cites W2043496047 @default.
- W2288362262 cites W2043542419 @default.
- W2288362262 cites W2045027192 @default.
- W2288362262 cites W2066989659 @default.
- W2288362262 cites W2082378475 @default.
- W2288362262 cites W2083676975 @default.
- W2288362262 cites W2085842281 @default.
- W2288362262 cites W2112732598 @default.
- W2288362262 cites W2118966363 @default.
- W2288362262 cites W2123361964 @default.
- W2288362262 cites W2133854477 @default.
- W2288362262 cites W2144139482 @default.
- W2288362262 cites W2165387177 @default.
- W2288362262 doi "https://doi.org/10.3109/10837450.2015.1135343" @default.
- W2288362262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26794504" @default.
- W2288362262 hasPublicationYear "2016" @default.
- W2288362262 type Work @default.
- W2288362262 sameAs 2288362262 @default.
- W2288362262 citedByCount "12" @default.
- W2288362262 countsByYear W22883622622018 @default.
- W2288362262 countsByYear W22883622622019 @default.
- W2288362262 countsByYear W22883622622020 @default.
- W2288362262 countsByYear W22883622622021 @default.
- W2288362262 countsByYear W22883622622022 @default.
- W2288362262 countsByYear W22883622622023 @default.
- W2288362262 crossrefType "journal-article" @default.
- W2288362262 hasAuthorship W2288362262A5013645115 @default.
- W2288362262 hasAuthorship W2288362262A5018860090 @default.
- W2288362262 hasAuthorship W2288362262A5034529578 @default.
- W2288362262 hasAuthorship W2288362262A5035166227 @default.
- W2288362262 hasAuthorship W2288362262A5055611807 @default.
- W2288362262 hasAuthorship W2288362262A5073357394 @default.
- W2288362262 hasAuthorship W2288362262A5091628026 @default.
- W2288362262 hasBestOaLocation W22883622622 @default.
- W2288362262 hasConcept C185592680 @default.
- W2288362262 hasConcept C195735259 @default.
- W2288362262 hasConcept C202751555 @default.
- W2288362262 hasConcept C26291073 @default.
- W2288362262 hasConcept C41625074 @default.
- W2288362262 hasConcept C43617362 @default.
- W2288362262 hasConcept C50670333 @default.
- W2288362262 hasConcept C55493867 @default.
- W2288362262 hasConcept C71924100 @default.
- W2288362262 hasConcept C98274493 @default.
- W2288362262 hasConceptScore W2288362262C185592680 @default.
- W2288362262 hasConceptScore W2288362262C195735259 @default.
- W2288362262 hasConceptScore W2288362262C202751555 @default.
- W2288362262 hasConceptScore W2288362262C26291073 @default.
- W2288362262 hasConceptScore W2288362262C41625074 @default.
- W2288362262 hasConceptScore W2288362262C43617362 @default.
- W2288362262 hasConceptScore W2288362262C50670333 @default.
- W2288362262 hasConceptScore W2288362262C55493867 @default.
- W2288362262 hasConceptScore W2288362262C71924100 @default.
- W2288362262 hasConceptScore W2288362262C98274493 @default.
- W2288362262 hasIssue "8" @default.
- W2288362262 hasLocation W22883622621 @default.
- W2288362262 hasLocation W22883622622 @default.
- W2288362262 hasLocation W22883622623 @default.
- W2288362262 hasOpenAccess W2288362262 @default.
- W2288362262 hasPrimaryLocation W22883622621 @default.
- W2288362262 hasRelatedWork W1531601525 @default.
- W2288362262 hasRelatedWork W2283447330 @default.
- W2288362262 hasRelatedWork W2319480705 @default.
- W2288362262 hasRelatedWork W2384464875 @default.
- W2288362262 hasRelatedWork W2606230654 @default.
- W2288362262 hasRelatedWork W2607424097 @default.
- W2288362262 hasRelatedWork W2748952813 @default.
- W2288362262 hasRelatedWork W2899084033 @default.
- W2288362262 hasRelatedWork W2948807893 @default.
- W2288362262 hasRelatedWork W2778153218 @default.
- W2288362262 hasVolume "22" @default.
- W2288362262 isParatext "false" @default.
- W2288362262 isRetracted "false" @default.
- W2288362262 magId "2288362262" @default.
- W2288362262 workType "article" @default.