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- W2288407789 abstract "Traumatic heterotopic ossification (HO) is the pathological formation of bone in soft tissue and is a debilitating sequelafollowing acute trauma involving blast-related extremity musculoskeletal injuries, severe burns, spinal cord injury, andtraumatic brain injury. Over 60% of combat related injuries and severe burns develop HO; often resulting in reducedmobility, chronic pain, ulceration, tissue entrapment, and reduced ambulation. Detection and prognosis is limited bycurrent clinical imaging modalities (computed tomography, radiography, and ultrasound). This study identifies Ramanspectral signatures corresponding to histological changes in a combat-trauma induced rat HO model at early time pointsprior to radiographic evidence of HO. HO was induced in Sprague-Dawley rats via blast over pressure injury, mid-femoralfracture, soft tissue crush injury, and limb amputation through the zone of injury. Rats were euthanized, andamputated limbs were formalin fixed and embedded in paraffin; 10 μm sections were placed on gold slides, and paraffinwas chemically removed. Tissues from sham-treated animals served as controls. Tissue maps consisting of Ramanspectra were generated using a Raman microprobe system with an 80-90 μm spot size and 785 nm excitation in regionsexhibiting histological evidence of early HO development according to adjacent HE sections. Factors were extractedfrom mapping data using Band-Target Entropy Minimization algorithms. Areas of early HO were highlighted by aRaman factor indicative of the presence of collagen. Identification of collagen as an early marker of HO prior toradiographic detection in a clinically relevant animal model serves to inform future clinical work." @default.
- W2288407789 created "2016-06-24" @default.
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- W2288407789 date "2016-02-29" @default.
- W2288407789 modified "2023-09-23" @default.
- W2288407789 title "Determining early markers of disease using Raman spectroscopy in a rat combat-trauma model of heterotopic ossification" @default.
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- W2288407789 doi "https://doi.org/10.1117/12.2213334" @default.
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