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- W2288451807 abstract "Today, the tablet is the most popular dosage form, covering around 50% of total oral drug delivery sys tem and accounting 75% of all pharmaceutical preparation pr oduced .It promotes statbility, portability and acc eptable patient compliance .The quality of solid dosage form is pri marily influenced by micromeritic characteristics s uch as the shape and size of drug crystal, especially in the c ase of poorly soluble drugs. To improve the dissolu tion rate of poorly soluble drugs, fine crystals are referred an d this micronisation can change drug powder propert ies such as wettability, compressibility, packability and flow. Further, it is more beneficial to convert micro cr ystalline drugs into an agglomerated form using spherical crystalli zation technique. The resulting spherically agglome rated crystals can be directly prepared into a tablet, thus direct tabletting saves time and reduces cost .General me thods of spherical crystallization are spherical agglomerati on, emulsion, solvent diffusion method, ammonia dif fusion method, neutralization method .The principle steps involved in the process of sc are flocculation zone , zero growth zone, fast growth zone, constant size zone .There i s a wide application of spherical crystallization:- improvement of flow ability, compressibility of poorly compressibl e drug, masking bitter taste of drug, improving sol ubility and dissolution rate of poorly soluble drug and thus im prove bioavailability of drug." @default.
- W2288451807 created "2016-06-24" @default.
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- W2288451807 date "2011-01-01" @default.
- W2288451807 modified "2023-09-27" @default.
- W2288451807 title "INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES Spherical crystallization -A novel drug delivery system" @default.
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- W2288451807 hasPublicationYear "2011" @default.
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