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- W2288521122 abstract "Offspring of spontar.eous colon tumor pror.e rats (WF /0) bred in our laboratory developed tumors in a very low incidence (less than 0. 2 %), but about half of these rats had dysplastic epithelium with frequent erosion in the caecum. In nine animals (4. 4%) submucosal glands of the caecum were observed. These dysplasia accomr:ariied inflammatory cell reactions and regional lymph nodes were enlarged and packed with many plasma cells. Hybrid of WF /0 rats and other inbred Long-Evans strain (LE) rats, having no dysplastic lesion of the caecum, had caecal dysplasia in a low incidence (10%). These data suggest that genetic factor(s) play an important role in the occurrence of caecal dysplasia in WF /0 rats. These changes may be a precondition to the spontaneous occurrence of tumors in the proximal portion of the ascending colon with the aid of promoting factor(s )." @default.
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- W2288521122 date "1983-09-01" @default.
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- W2288521122 title "High prevalence of caecal dysplasia in Wistar/Furth substrain rats." @default.
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