Matches in SemOpenAlex for { <https://semopenalex.org/work/W2288549710> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2288549710 abstract "Objective: To describe therapeutic features of 120 panic disorder (PD) patients treated with clonazepam, paroxetine, or clonazepam + paroxetine for 3 years and their follow-up for more 6 years. Method: A prospective open study randomized 120 PD patients to 2 mg/day clonazepam or 40 mg/day paroxetine. Poor responders were switched after 8 weeks to combined treatment with ∼2 mg/day clonazepam + ∼40 mg/day paroxetine. Tapered withdrawal of all treatments was performed after 3 years. Efficacy, safety, and cumulative relapse and remission were studied over the following 6 years, using panic attack (PA) count, clinical global impression-severity (CGI-S), and Hamilton anxiety scale (HAMA). Results: 94 patients completed 3 years treatment. All were free of panic attacks since at least one year before undergoing tapered drug withdrawal. After two months of tapering, 80% of clonazepam patients were drug-free, versus 55% on paroxetine. No serious or severe adverse event were observed but PA/month, CGI-S, and HAMA worsened slightly. In annually studied patients the relapse rates were similar after the 3 treatments with an advantage of clonazepam over the combination (p=0.0035) and paroxetine (p=0.08, exact Fisher) at the first year after drug withdrawal. C umulative relapses rate were 41%, 77%, and 94% at years 1, 4, and 6, but relapse therapy with either clonazepam or paroxetine was successful in nearly all cases. Conclusion: PD is a chronic disorder, with many patients relapsing after 3 years treatment. Response to retreatment was excellent. Paroxetine and clonazepam were associated with similar long-term prognoses but clonazepam was better tolerated." @default.
- W2288549710 created "2016-06-24" @default.
- W2288549710 creator A5005797528 @default.
- W2288549710 creator A5016638392 @default.
- W2288549710 creator A5028666576 @default.
- W2288549710 creator A5040072237 @default.
- W2288549710 creator A5044288506 @default.
- W2288549710 creator A5052598738 @default.
- W2288549710 creator A5060171342 @default.
- W2288549710 date "2015-03-01" @default.
- W2288549710 modified "2023-10-17" @default.
- W2288549710 title "Prospective, Open, Randomized 3-years Long-term Treatment of Panic Disorder with Clonazepam, Paroxetine, or Their Combination and Follow-up During Additional 6 Years" @default.
- W2288549710 doi "https://doi.org/10.1016/s0924-9338(15)31846-0" @default.
- W2288549710 hasPublicationYear "2015" @default.
- W2288549710 type Work @default.
- W2288549710 sameAs 2288549710 @default.
- W2288549710 citedByCount "2" @default.
- W2288549710 countsByYear W22885497102016 @default.
- W2288549710 countsByYear W22885497102020 @default.
- W2288549710 crossrefType "journal-article" @default.
- W2288549710 hasAuthorship W2288549710A5005797528 @default.
- W2288549710 hasAuthorship W2288549710A5016638392 @default.
- W2288549710 hasAuthorship W2288549710A5028666576 @default.
- W2288549710 hasAuthorship W2288549710A5040072237 @default.
- W2288549710 hasAuthorship W2288549710A5044288506 @default.
- W2288549710 hasAuthorship W2288549710A5052598738 @default.
- W2288549710 hasAuthorship W2288549710A5060171342 @default.
- W2288549710 hasConcept C118552586 @default.
- W2288549710 hasConcept C126322002 @default.
- W2288549710 hasConcept C142724271 @default.
- W2288549710 hasConcept C15744967 @default.
- W2288549710 hasConcept C197934379 @default.
- W2288549710 hasConcept C204787440 @default.
- W2288549710 hasConcept C27081682 @default.
- W2288549710 hasConcept C2776000289 @default.
- W2288549710 hasConcept C2776317618 @default.
- W2288549710 hasConcept C2777196872 @default.
- W2288549710 hasConcept C2777529043 @default.
- W2288549710 hasConcept C2777828372 @default.
- W2288549710 hasConcept C2778062832 @default.
- W2288549710 hasConcept C2779177272 @default.
- W2288549710 hasConcept C2779426884 @default.
- W2288549710 hasConcept C2780035454 @default.
- W2288549710 hasConcept C2780712732 @default.
- W2288549710 hasConcept C42219234 @default.
- W2288549710 hasConcept C558461103 @default.
- W2288549710 hasConcept C71924100 @default.
- W2288549710 hasConceptScore W2288549710C118552586 @default.
- W2288549710 hasConceptScore W2288549710C126322002 @default.
- W2288549710 hasConceptScore W2288549710C142724271 @default.
- W2288549710 hasConceptScore W2288549710C15744967 @default.
- W2288549710 hasConceptScore W2288549710C197934379 @default.
- W2288549710 hasConceptScore W2288549710C204787440 @default.
- W2288549710 hasConceptScore W2288549710C27081682 @default.
- W2288549710 hasConceptScore W2288549710C2776000289 @default.
- W2288549710 hasConceptScore W2288549710C2776317618 @default.
- W2288549710 hasConceptScore W2288549710C2777196872 @default.
- W2288549710 hasConceptScore W2288549710C2777529043 @default.
- W2288549710 hasConceptScore W2288549710C2777828372 @default.
- W2288549710 hasConceptScore W2288549710C2778062832 @default.
- W2288549710 hasConceptScore W2288549710C2779177272 @default.
- W2288549710 hasConceptScore W2288549710C2779426884 @default.
- W2288549710 hasConceptScore W2288549710C2780035454 @default.
- W2288549710 hasConceptScore W2288549710C2780712732 @default.
- W2288549710 hasConceptScore W2288549710C42219234 @default.
- W2288549710 hasConceptScore W2288549710C558461103 @default.
- W2288549710 hasConceptScore W2288549710C71924100 @default.
- W2288549710 hasLocation W22885497101 @default.
- W2288549710 hasOpenAccess W2288549710 @default.
- W2288549710 hasPrimaryLocation W22885497101 @default.
- W2288549710 hasRelatedWork W1971445009 @default.
- W2288549710 hasRelatedWork W1974976450 @default.
- W2288549710 hasRelatedWork W1980978852 @default.
- W2288549710 hasRelatedWork W1988030263 @default.
- W2288549710 hasRelatedWork W2030116324 @default.
- W2288549710 hasRelatedWork W2038509039 @default.
- W2288549710 hasRelatedWork W2039455724 @default.
- W2288549710 hasRelatedWork W2061957471 @default.
- W2288549710 hasRelatedWork W2067927385 @default.
- W2288549710 hasRelatedWork W2086439600 @default.
- W2288549710 hasRelatedWork W2086858917 @default.
- W2288549710 hasRelatedWork W2091022482 @default.
- W2288549710 hasRelatedWork W2143270976 @default.
- W2288549710 hasRelatedWork W2169299701 @default.
- W2288549710 hasRelatedWork W2396396784 @default.
- W2288549710 hasRelatedWork W2418061984 @default.
- W2288549710 hasRelatedWork W2431225882 @default.
- W2288549710 hasRelatedWork W2435207710 @default.
- W2288549710 hasRelatedWork W2497408675 @default.
- W2288549710 hasRelatedWork W2938326 @default.
- W2288549710 isParatext "false" @default.
- W2288549710 isRetracted "false" @default.
- W2288549710 magId "2288549710" @default.
- W2288549710 workType "article" @default.