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- W2288559949 abstract "Exposure to endogenous and exogenous chemicals can lead to modification of DNA and potentially lead to cancer. Frameshift mutations may be a consequence of these modifications to DNA. Oligonucleotides were synthesized that contain a site specific a site specific C8-deoxyguanosine adduct 2-amino-3-methylnaphtho[1,2-d]imidazole (CCIQ), which is an analogue of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), and the adducts R- and S-Ai-methyl-A£-hydroxy-1,N2-propano-2â-deoxyguaosine and A£-hydroxy-1,N2-propano-2â-deoxyguanosine in frameshift prone sequences. In vitro replication studies were conducted to examine which nucleotide was incorporated opposite the adducts by a variety of DNA polymerases. The sequence and yields of the extension products were determined using tandem mass spectrometry." @default.
- W2288559949 created "2016-06-24" @default.
- W2288559949 creator A5078871765 @default.
- W2288559949 date "2008-12-15" @default.
- W2288559949 modified "2023-09-24" @default.
- W2288559949 title "In vitro replication studies of oligonucleotides containing site-specific DNA adducts in frameshift-prone sequences" @default.
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