FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W22885736> ?p ?o ?g. }

• W22885736 endingPage "189" @default.
• W22885736 startingPage "163" @default.
• W22885736 abstract "Eyeblink classical conditioning is a useful model system for the study of the neurobiology of learning, memory, and aging which also has application to dementia. Parallel age differences in conditioning in the short-delay procedure appear in middle age in rabbits and humans that may be caused at least in part by loss of cerebellar Purkinje cells. It is only when the CS-US interval is extended to 1500 ms that the age differences in delay eyeblink classical conditioning disappear. The smaller body of evidence on the effects of normal aging in the trace, discrimination, and other complex classical conditioning procedures also suggests age-related impairment. Eyeblink classical conditioning has relevance to AD because of the involvement of the hippocampal cholinergic system. AD profoundly affects the hippocampal cholinergic system, and our observation that Alzheimer’s patients condition poorly or not at all may be related to the abnormally functioning hippocampus and loss of hippocampal CA1 pyramidal cells. Alzheimer’s patients and patients with Down’s syndrome and AD consistently perform poorly in eyeblink conditioning, but patients with dementia diagnosed as cerebrovascular dementia are not consistently poor conditioners. We suspect that CVD patients condition poorly only when some of the circuitry involved in classical conditioning has been affected. Patients with HD, PD, and Fragile X syndrome condition as well as normal age-matched adults. Eyeblink conditioning may be useful in differential diagnosis in dementia and also in detecting AD early in its onset. Because eyeblink conditioning is simple, non-threatening, and non-invasive, it may become a useful addition to test batteries designed to differentiate normal aging from dementia and AD from other types of dementia. Eyeblink conditioning may also detect AD early, before declarative memory impairment is evident." @default.
• W22885736 created "2016-06-24" @default.
• W22885736 creator A5040479355 @default.
• W22885736 date "2005-12-11" @default.
• W22885736 modified "2023-09-24" @default.
• W22885736 title "Human Eyeblink Classical Conditoning in Normal Aging and Alzheimer’s Disease" @default.
• W22885736 cites W1893261625 @default.
• W22885736 cites W1971244565 @default.
• W22885736 cites W1974644793 @default.
• W22885736 cites W1974715319 @default.
• W22885736 cites W1980225806 @default.
• W22885736 cites W1983280978 @default.
• W22885736 cites W1983728847 @default.
• W22885736 cites W1984085497 @default.
• W22885736 cites W1984214648 @default.
• W22885736 cites W1990753810 @default.
• W22885736 cites W1992214067 @default.
• W22885736 cites W1992877651 @default.
• W22885736 cites W1996020926 @default.
• W22885736 cites W1998652901 @default.
• W22885736 cites W2011675785 @default.
• W22885736 cites W2014916009 @default.
• W22885736 cites W2015532932 @default.
• W22885736 cites W2018619381 @default.
• W22885736 cites W2025384876 @default.
• W22885736 cites W2034053464 @default.
• W22885736 cites W2037039368 @default.
• W22885736 cites W2038032519 @default.
• W22885736 cites W2040657121 @default.
• W22885736 cites W2042014678 @default.
• W22885736 cites W2042945484 @default.
• W22885736 cites W2050704896 @default.
• W22885736 cites W2051510048 @default.
• W22885736 cites W2052637450 @default.
• W22885736 cites W2052919352 @default.
• W22885736 cites W2057450358 @default.
• W22885736 cites W2062638293 @default.
• W22885736 cites W2063291293 @default.
• W22885736 cites W2064933313 @default.
• W22885736 cites W2083166581 @default.
• W22885736 cites W2085713021 @default.
• W22885736 cites W2088378257 @default.
• W22885736 cites W2101124117 @default.
• W22885736 cites W2101728600 @default.
• W22885736 cites W2101983808 @default.
• W22885736 cites W2102724497 @default.
• W22885736 cites W2112875298 @default.
• W22885736 cites W2114806855 @default.
• W22885736 cites W2115483917 @default.
• W22885736 cites W2124365503 @default.
• W22885736 cites W2156374127 @default.
• W22885736 cites W2158437989 @default.
• W22885736 cites W2158478804 @default.
• W22885736 cites W2171405125 @default.
• W22885736 cites W2171911202 @default.
• W22885736 cites W2188044740 @default.
• W22885736 cites W4230471184 @default.
• W22885736 cites W4232606784 @default.
• W22885736 cites W4232959226 @default.
• W22885736 cites W4234082070 @default.
• W22885736 cites W4234962100 @default.
• W22885736 cites W4235976996 @default.
• W22885736 cites W4237339765 @default.
• W22885736 cites W4240135549 @default.
• W22885736 cites W4240980427 @default.
• W22885736 cites W4242878010 @default.
• W22885736 cites W4244852295 @default.
• W22885736 cites W4245363136 @default.
• W22885736 cites W4248213715 @default.
• W22885736 cites W4249414560 @default.
• W22885736 cites W4251301348 @default.
• W22885736 cites W4251492017 @default.
• W22885736 cites W4322695843 @default.
• W22885736 cites W49881644 @default.
• W22885736 doi "https://doi.org/10.1007/0-306-46896-4_8" @default.
• W22885736 hasPublicationYear "2005" @default.
• W22885736 type Work @default.
• W22885736 sameAs 22885736 @default.
• W22885736 citedByCount "1" @default.
• W22885736 countsByYear W228857362020 @default.
• W22885736 crossrefType "book-chapter" @default.
• W22885736 hasAuthorship W22885736A5040479355 @default.
• W22885736 hasConcept C105795698 @default.
• W22885736 hasConcept C126322002 @default.
• W22885736 hasConcept C148762608 @default.
• W22885736 hasConcept C15744967 @default.
• W22885736 hasConcept C169760540 @default.
• W22885736 hasConcept C2779134260 @default.
• W22885736 hasConcept C2779483572 @default.
• W22885736 hasConcept C2781081984 @default.
• W22885736 hasConcept C2781161787 @default.
• W22885736 hasConcept C33923547 @default.
• W22885736 hasConcept C39617858 @default.
• W22885736 hasConcept C45262634 @default.
• W22885736 hasConcept C71924100 @default.
• W22885736 hasConceptScore W22885736C105795698 @default.
• W22885736 hasConceptScore W22885736C126322002 @default.
• W22885736 hasConceptScore W22885736C148762608 @default.

• next