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- W2288578632 endingPage "217" @default.
- W2288578632 startingPage "202" @default.
- W2288578632 abstract "In spite of significant advances in antiretroviral (ARV) therapy, the elimination of human immunodeficiency virus (HIV) reservoirs from the periphery and the central nervous system (CNS) remains a formidable task. The incapability of ARV to go across the blood-brain barrier (BBB) after systemic administration makes the brain one of the dominant HIV reservoirs. Thus, screening, monitoring, and elimination of HIV reservoirs from the brain remain a clinically daunting and key task. The practice and investigation of nanomedicine possesses potentials for therapeutics against neuroAIDS. This review highlights the advancements in nanoscience and nanotechnology to design and develop specific size therapeutic cargo for efficient navigation across BBB so as to recognize and eradicate HIV brain reservoirs. Different navigation and drug release strategies, their biocompatibility and efficacy with related challenges and future prospects are also discussed. This review would be an excellent platform to understand nano-enable multidisciplinary research to formulate efficient nanomedicine for the management of neuroAIDS." @default.
- W2288578632 created "2016-06-24" @default.
- W2288578632 creator A5012390032 @default.
- W2288578632 creator A5035134617 @default.
- W2288578632 creator A5047076583 @default.
- W2288578632 creator A5088624682 @default.
- W2288578632 date "2016-08-01" @default.
- W2288578632 modified "2023-10-13" @default.
- W2288578632 title "Getting into the brain: Potential of nanotechnology in the management of NeuroAIDS" @default.
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