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• W2288593978 abstract "To evaluate whether changes of dynamic contrast-enhanced ultrasound (CEUS)-based liver microcirculation during chronic liver disease are correlated with the extent of impaired liver function, expressed by the indocyanine green (ICG) clearance.19 patients underwent CEUS examinations with previous or consecutive ICG clearance test. The ICG plasma disappearance rate (ICG-PDR) was determined using the noninvasive pulse-densitometric LiMON system. Quantification of peak enhancement (PE), rise time (RT) and the wash-in rate (WiR) was performed in the liver parenchyma (ROIliver) as well as in the portal vein (ROIportal vein) using a novel quantification software (VueBoxTM). To compare quantification parameters, patients were classified in patients representing a healthy population (ICG-PDR >16, n = 8) and those representing patients with liver disease (ICG-PDR ≤16, n = 11).ROIportal vein showed significant differences comparing healthy patients and patients with liver disease for all perfusion parameters: PE and WiR were significantly higher in patients without liver disease (p = 0.048; p = 0.039). RT was significantly lower in healthy population (p = 0.039). Comparing perfusion parameters for ROIliver, PE was significantly higher in patients without liver disease (p = 0.039). There was no significant difference for RT (p = 0.804) and WiR (p = 0.058), respectively.Within the framework of this study CEUS derived estimation of microcirculation did not prove to be a reliable estimator of liver function. RT, PE and WiR measured in the portal vein were significant perfusion factors in predicting liver function." @default.
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• W2288593978 date "2015-09-09" @default.
• W2288593978 modified "2023-09-27" @default.
• W2288593978 title "Chronic liver disease: Correlation of CEUS-based microperfusion and indocyanine green clearance" @default.
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• W2288593978 doi "https://doi.org/10.3233/ch-151990" @default.
• W2288593978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26410870" @default.
• W2288593978 hasPublicationYear "2015" @default.
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