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• W2288595536 abstract "Genetic selection and increased understanding of nutrition over the last decade or so has led to tremendous improvements in the efficient production of highquality lean pork. A characteristic of these leaner pigs is that they have higher levels of the naturally occurring hormone, somatotropin (or growth hormone). It has been known for several decades that injection of pigs with tissue extracts containing porcine somatotropin (pST) results in increased lean tissue deposition and decreased fat accretion in growing pigs. Advances in biotechnology have now provided a means of producing PST on a commercial scale and the efficacy of daily injection of recombinantly-derived pST for improving productive performance of swine is beyond doubt. Administration of PST has to be via daily injection, or as a slow release device because PST is a peptide hormone and is digested if given in the feed. However, a group of orally-active compounds which alter the ratio of lean to fat deposition have recently become available for research purposes and currently being trialed for commercial use. This group of compounds, which includes ractopamine, salbutamol, cimaterol, clenbuter01, Ro 16-87 14, BRL-47672 and L-644,969, are broadly called R-agonists because they all act through the Isreceptors on the target tissues. Hence, one of the acute actions of l3-agonists on fat tissue is to decrease fat synthesis and to increase fat breakdown. The actions on lean tissue are less well documented but probably the l3agonists decrease skeletal muscle protein breakdown. The actions of a Dunshea, 1993) and therefore the aim of this paper is not to cover this area again but rather to discuss some of the factors which may interact with D-agonists and influence their efficacy. These factors include non-nutritional factors such as dose, genotype, sex, duration of treatment and age of the animals and nutritional factors such as dietary protein and energy. The structure of the D-agonist also determines efficacy and the reader is referred to the review by Timmerman (1987) for the attributes of potential nutrient partitioning agents. Non-Nutritional Factors" @default.
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• W2288595536 date "1995-01-01" @default.
• W2288595536 modified "2023-09-28" @default.
• W2288595536 title "Nutritional and other factors affecting efficacy of B-agonists in pigs." @default.
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