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- W2288610283 abstract "6platelets) in a series of pat ients with chronic leukemias and myeloproliferative disorders. The highest serum levels were observed in patients with chronic myeloid leukemia (CML ) and myelofibrosis with myeloid metaplasia (MMM). These findings suggests that VEGF serum levels may surrogate the increased bone marrow (BM) angiogenesis characterizing either CML or MMM. Angiogenesis has a major role in tumor growth, dissemina tion and metastasis of solid tumors.1 The reported increa sed bone marrow (BM) vascularity in acute lymphoblastic leukemia (AL L), acute myeloblastic leukemia (AML) and myelodyspla stic syndromes (MDS), the prognostic importance of va scular endothelial growth factor (V EGF) in AML and the detection of angiogenic factor receptors in leukemia cell lines suggest that angiogenesis has a central role in the pathophysiology of leukemias. 2 Agua yo et al.3 evaluated the role of V EGF protein in the leukemogenic process of chronic leukemia s ta king into a ccount the pattern of increase of different angiogenic factors. The highest plasma levels of VEGF were found in chronic myeloid leukemia (CML) and the lowest in chronic lymphocytic leukemia (CL L). Information dealing with other myeloproliferative disorders such as essential thrombocythemia (ET) or myelofibrosis with myeloid metaplasia (MMM) are lacking." @default.
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- W2288610283 date "2001-07-01" @default.
- W2288610283 modified "2023-10-16" @default.
- W2288610283 title "Serum levels of vascular endothelial growth factor in chronic leukemias. A comparative study with emphasis on myeloproliferative disorders." @default.
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