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• W2288628385 abstract "Influenza B viruses split into 2 distinct lineages in the early 1980s, commonly named the Victoria and Yamagata lineages. There are few data on the comparative epidemiology of Victoria- and Yamagata-lineage viruses. In 2007-2011, we enrolled 75 and 34 households containing index patients with acute respiratory illness who tested positive for Yamagata- and Victoria-lineage viruses, respectively, from outpatient clinics in Hong Kong, China. These index patients and their household contacts were followed up for 7-10 days. We examined overall risk of polymerase chain reaction-confirmed infection among household contacts and the risk of secondary infection within households using an individual-based hazard model that accounted for tertiary transmission and infections occurring outside the household. We found that for Victoria-lineage viruses, the risk of within-household infection among household contacts aged ≤15 years was significantly higher (risk ratio = 12.9, 95% credibility interval: 4.2, 43.6) than that for older household contacts, while for Yamagata-lineage viruses, the risk of within-household infection for household contacts did not differ by age. Influenza B Yamagata- and Victoria-lineage viruses have similar characteristics in terms of viral shedding and clinical illness. The mechanisms underlying these epidemiologic differences deserve further investigation." @default.
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• W2288628385 date "2015-09-22" @default.
• W2288628385 modified "2023-10-12" @default.
• W2288628385 title "Comparative Epidemiology of Influenza B Yamagata- and Victoria-Lineage Viruses in Households" @default.
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• W2288628385 doi "https://doi.org/10.1093/aje/kwv110" @default.
• W2288628385 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4715237" @default.
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• W2288628385 hasPublicationYear "2015" @default.
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