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- W2288696301 abstract "Clostridium ljungdahlii is an important synthesis gas-fermenting bacterium used in the biofuels industry, and a preliminary investigation showed that it has some tolerance to oxygen when cultured in rich mixotrophic medium. Batch cultures not only continue to grow and consume H2, CO, and fructose after 8% O2 exposure, but fermentation product analysis revealed an increase in ethanol concentration and decreased acetate concentration compared to non-oxygen-exposed cultures. In this study, the mechanisms for higher ethanol production and oxygen/reactive oxygen species (ROS) detoxification were identified using a combination of fermentation, transcriptome sequencing (RNA-seq) differential expression, and enzyme activity analyses. The results indicate that the higher ethanol and lower acetate concentrations were due to the carboxylic acid reductase activity of a more highly expressed predicted aldehyde oxidoreductase (CLJU_c24130) and that C. ljungdahlii's primary defense upon oxygen exposure is a predicted rubrerythrin (CLJU_c39340). The metabolic responses of higher ethanol production and oxygen/ROS detoxification were found to be linked by cofactor management and substrate and energy metabolism. This study contributes new insights into the physiology and metabolism of C. ljungdahlii and provides new genetic targets to generate C. ljungdahlii strains that produce more ethanol and are more tolerant to syngas contaminants." @default.
- W2288696301 created "2016-06-24" @default.
- W2288696301 creator A5003567780 @default.
- W2288696301 creator A5014532044 @default.
- W2288696301 creator A5051755119 @default.
- W2288696301 creator A5054551778 @default.
- W2288696301 creator A5080516494 @default.
- W2288696301 date "2015-12-15" @default.
- W2288696301 modified "2023-09-30" @default.
- W2288696301 title "Metabolic Response of Clostridium ljungdahlii to Oxygen Exposure" @default.
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