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- W2288707943 abstract "Helicobacter pylori is the dominant member of the gastric microbiota in over half of the human population of which 5–15% develop gastritis or gastric malignancies. Immune responses to H. pylori are characterized by mixed T helper cell, cytotoxic T cell and NK cell responses. The presence of Tregs is essential for the control of gastritis and together with regulatory CX3CR1+ mononuclear phagocytes and immune-evasion strategies they enable life-long persistence of H. pylori. This H. pylori-induced regulatory environment might contribute to its cross-protective effect in inflammatory bowel disease and obesity. Here we review host-microbe interactions, the development of pro- and anti-inflammatory immune responses and how the latter contribute to H. pylori's role as beneficial member of the gut microbiota. Furthermore, we present the integration of existing and new data into a computational/mathematical model and its use for the investigation of immunological mechanisms underlying initiation, progression and outcomes of H. pylori infection." @default.
- W2288707943 created "2016-06-24" @default.
- W2288707943 creator A5002755805 @default.
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- W2288707943 creator A5058888863 @default.
- W2288707943 creator A5069323009 @default.
- W2288707943 creator A5087379114 @default.
- W2288707943 date "2016-01-02" @default.
- W2288707943 modified "2023-10-16" @default.
- W2288707943 title "Systems-wide analyses of mucosal immune responses to<i>Helicobacter pylori</i>at the interface between pathogenicity and symbiosis" @default.
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