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- W2288778775 abstract "The objective of this study is to develop floating drug delivery system; specially floating tablet of Tramadol Hydrochloride (TH). Floating delivery system of TH was prepared using different grades of HPMC as drug release retarding polymer and sodium bicarbonate as source for carbon dioxide which helps tablets to float. From FTIR studies no interactions were found between TH and polymers. The flow properties of the granules were studied and formulation F5 was found to have comparatively good compressibility index and hausner ratio than other formulations. From the swelling study of the formulations, formulation F5 was found to have good swelling properties (220%). From the dissolution studies of the formulations, formulation F5 was found to have better drug release profile than other formulations. From the drug release kinetic study, Higuchi model was found to be best fit. So it could be predicted that release of TH from the floating drug delivery formulations were of diffusion type." @default.
- W2288778775 created "2016-06-24" @default.
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- W2288778775 date "2010-01-01" @default.
- W2288778775 modified "2023-09-23" @default.
- W2288778775 title "DESIGNING AND INVITRO STUDIES OF GASTRIC FLOATING TABLETS OF TRAMADOL HYDROCHLORIDE" @default.
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