Matches in SemOpenAlex for { <https://semopenalex.org/work/W2288782762> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2288782762 abstract "A water soluble derivative of 4,5'-dimethylangelicin (I) having a long chain linking an amino group to the planar furocoumarinic moiety, that is 4'-N,N-dimethylaminoethoxymethyl-4,5'-dimethylangelicin (III), has been prepared. This compound is able to form effectively the intercalated complex with DNA like the previously prepared 4'-aminomethyl-4,5'-dimethylangelicin (II), however while the compound (II) showed very poor photobinding to DNA, the new derivative (III) shows high photobinding to the macromolecule. It is proposed that these data illustrate the importance of the geometry of intercalation for the subsequent covalent photobinding to the macromolecule. Also some photophysical data of (II) and of (III) appear to confirm the critical role of the position assumed by the chromophore of the two compounds when intercalated in duplex DNA. The compound (III) displays high photobiological effects, also in terms of antiproliferative activity as shown by its capacity to inhibit DNA and RNA synthesis in Ehrlich cells, the growth of an E. coli culture and the infectivity of T2 phage. (III) on the basis of these properties seems to deserve a clinical evaluation of its potential photochemotherapeutic activity in the treatment of psoriasis." @default.
- W2288782762 created "2016-06-24" @default.
- W2288782762 creator A5015931497 @default.
- W2288782762 creator A5016761751 @default.
- W2288782762 creator A5026566548 @default.
- W2288782762 creator A5027477340 @default.
- W2288782762 creator A5028408032 @default.
- W2288782762 creator A5035818670 @default.
- W2288782762 creator A5044015765 @default.
- W2288782762 creator A5057626848 @default.
- W2288782762 creator A5085292075 @default.
- W2288782762 date "1981-11-03" @default.
- W2288782762 modified "2023-09-26" @default.
- W2288782762 title "ChemInform Abstract: A NEW WATER SOLUBLE DERIVATIVE OF 4,5′-DIMETHYLANGELICIN AS A POTENTIAL AGENT FOR PHOTOCHEMOTHERAPY" @default.
- W2288782762 doi "https://doi.org/10.1002/chin.198144194" @default.
- W2288782762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7274439" @default.
- W2288782762 hasPublicationYear "1981" @default.
- W2288782762 type Work @default.
- W2288782762 sameAs 2288782762 @default.
- W2288782762 citedByCount "1" @default.
- W2288782762 crossrefType "journal-article" @default.
- W2288782762 hasAuthorship W2288782762A5015931497 @default.
- W2288782762 hasAuthorship W2288782762A5016761751 @default.
- W2288782762 hasAuthorship W2288782762A5026566548 @default.
- W2288782762 hasAuthorship W2288782762A5027477340 @default.
- W2288782762 hasAuthorship W2288782762A5028408032 @default.
- W2288782762 hasAuthorship W2288782762A5035818670 @default.
- W2288782762 hasAuthorship W2288782762A5044015765 @default.
- W2288782762 hasAuthorship W2288782762A5057626848 @default.
- W2288782762 hasAuthorship W2288782762A5085292075 @default.
- W2288782762 hasConcept C106159729 @default.
- W2288782762 hasConcept C111771559 @default.
- W2288782762 hasConcept C137824038 @default.
- W2288782762 hasConcept C162324750 @default.
- W2288782762 hasConcept C178790620 @default.
- W2288782762 hasConcept C180577832 @default.
- W2288782762 hasConcept C185592680 @default.
- W2288782762 hasConcept C192468462 @default.
- W2288782762 hasConcept C204389451 @default.
- W2288782762 hasConcept C21951064 @default.
- W2288782762 hasConcept C2776568683 @default.
- W2288782762 hasConcept C2777626080 @default.
- W2288782762 hasConcept C552990157 @default.
- W2288782762 hasConcept C55493867 @default.
- W2288782762 hasConcept C71240020 @default.
- W2288782762 hasConceptScore W2288782762C106159729 @default.
- W2288782762 hasConceptScore W2288782762C111771559 @default.
- W2288782762 hasConceptScore W2288782762C137824038 @default.
- W2288782762 hasConceptScore W2288782762C162324750 @default.
- W2288782762 hasConceptScore W2288782762C178790620 @default.
- W2288782762 hasConceptScore W2288782762C180577832 @default.
- W2288782762 hasConceptScore W2288782762C185592680 @default.
- W2288782762 hasConceptScore W2288782762C192468462 @default.
- W2288782762 hasConceptScore W2288782762C204389451 @default.
- W2288782762 hasConceptScore W2288782762C21951064 @default.
- W2288782762 hasConceptScore W2288782762C2776568683 @default.
- W2288782762 hasConceptScore W2288782762C2777626080 @default.
- W2288782762 hasConceptScore W2288782762C552990157 @default.
- W2288782762 hasConceptScore W2288782762C55493867 @default.
- W2288782762 hasConceptScore W2288782762C71240020 @default.
- W2288782762 hasLocation W22887827621 @default.
- W2288782762 hasLocation W22887827622 @default.
- W2288782762 hasOpenAccess W2288782762 @default.
- W2288782762 hasPrimaryLocation W22887827621 @default.
- W2288782762 hasRelatedWork W1163641162 @default.
- W2288782762 hasRelatedWork W2058481163 @default.
- W2288782762 hasRelatedWork W2092965211 @default.
- W2288782762 hasRelatedWork W2113446496 @default.
- W2288782762 hasRelatedWork W2173835085 @default.
- W2288782762 hasRelatedWork W2288782762 @default.
- W2288782762 hasRelatedWork W2412715195 @default.
- W2288782762 hasRelatedWork W2418939575 @default.
- W2288782762 hasRelatedWork W2752809907 @default.
- W2288782762 hasRelatedWork W4281692041 @default.
- W2288782762 isParatext "false" @default.
- W2288782762 isRetracted "false" @default.
- W2288782762 magId "2288782762" @default.
- W2288782762 workType "article" @default.